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GPS1 G protein pathway suppressor 1 [ Homo sapiens (human) ]

Gene ID: 2873, updated on 27-Nov-2024

Summary

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Official Symbol
GPS1provided by HGNC
Official Full Name
G protein pathway suppressor 1provided by HGNC
Primary source
HGNC:HGNC:4549
See related
Ensembl:ENSG00000169727 MIM:601934; AllianceGenome:HGNC:4549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN1; SGN1; COPS1
Summary
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in kidney (RPKM 28.1), testis (RPKM 27.1) and 25 other tissues See more
Orthologs
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Genomic context

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See GPS1 in Genome Data Viewer
Location:
17q25.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82050932..82057470)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82918090..82924628)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80008808..80015346)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9184 Neighboring gene DCXR divergent transcript Neighboring gene dicarbonyl and L-xylulose reductase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80009332-80010001 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80022320-80023048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9190 Neighboring gene MPRA-validated peak3028 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80038893-80039778 Neighboring gene fatty acid synthase Neighboring gene small nucleolar RNA, C/D box 134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Bioinformatics analysis of GPS1 expression and biological function in breast cancer. Wei H, et al. J Cancer Res Clin Oncol, 2024 Jan 30. PMID 38289496, Free PMC Article
  2. UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis. Dubois EL, et al. Oncol Rep, 2016 May. PMID 26986008, Free PMC Article
  3. CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1. Tsuge T, et al. Protein Cell, 2011 May. PMID 21604193, Free PMC Article
  4. CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. Fu H, et al. Mol Med Rep, 2021 Jan. PMID 33200803, Free PMC Article
  5. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Feber A, et al. Cancer Res, 2016 Aug 15. PMID 27325650, Free PMC Article

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bioinformatics analysis of GPS1 expression and biological function in breast cancer.
    Title: Bioinformatics analysis of GPS1 expression and biological function in breast cancer.
  2. CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.
    Title: CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.
  3. We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1
    Title: CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.
  4. CSN1 appears to play a role not only in DNA repair but also in UV-induced apoptosis.
    Title: UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.
  5. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.
    Title: Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.
  6. An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia.
    Title: Altered expression of COP9 signalosome proteins in preeclampsia.
  7. CSN1 inhibits c-Jun phosphorylation without affecting its protein stability.
    Title: CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.
  8. The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome.
    Title: The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with G protein pathway suppressor 1 (GPS1; COPS1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC71287

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein deneddylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein neddylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of protein neddylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of COP9 signalosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 1
Names
JAB1-containing signalosome subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321089.3 → NP_001308018.1  COP9 signalosome complex subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    A0A9L9PXT0, B4DND6
    Related
    ENSP00000516490.1, ENST00000706669.1
    Conserved Domains (2) summary
    pfam01399
    Location:392 → 496
    PCI; PCI domain
    pfam10602
    Location:195 → 377
    RPN7; 26S proteasome subunit RPN7

  2. NM_001321090.3 → NP_001308019.1  COP9 signalosome complex subunit 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:388 → 492
    PCI; PCI domain
    pfam10602
    Location:191 → 373
    RPN7; 26S proteasome subunit RPN7

  3. NM_001321091.3 → NP_001308020.1  COP9 signalosome complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:387 → 491
    PCI; PCI domain
    pfam10602
    Location:191 → 372
    RPN7; 26S proteasome subunit RPN7

  4. NM_001321092.3 → NP_001308021.1  COP9 signalosome complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS82226.1
    UniProtKB/TrEMBL
    B4DND6
    Related
    ENSP00000462265.1, ENST00000578552.6
    Conserved Domains (2) summary
    pfam01399
    Location:320 → 424
    PCI; PCI domain
    pfam10602
    Location:123 → 305
    RPN7; 26S proteasome subunit RPN7

  5. NM_001321093.3 → NP_001308022.1  COP9 signalosome complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS82228.1
    UniProtKB/TrEMBL
    B4DND6, C9JFE4
    Related
    ENSP00000313569.4, ENST00000320548.8
    Conserved Domains (2) summary
    pfam01399
    Location:304 → 408
    PCI; PCI domain
    pfam10602
    Location:107 → 289
    RPN7; 26S proteasome subunit RPN7

  6. NM_001330539.3 → NP_001317468.1  COP9 signalosome complex subunit 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS82227.1
    UniProtKB/TrEMBL
    A0A096LP07, B4DND6
    Related
    ENSP00000485330.1, ENST00000623691.3
    Conserved Domains (2) summary
    pfam01399
    Location:319 → 423
    PCI; PCI domain
    pfam10602
    Location:123 → 304
    RPN7; 26S proteasome subunit RPN7

  7. NM_001330541.3 → NP_001317470.1  COP9 signalosome complex subunit 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS82225.1
    UniProtKB/TrEMBL
    A0A096LPJ3, B4DND6
    Related
    ENSP00000485641.1, ENST00000624957.3
    Conserved Domains (2) summary
    pfam01399
    Location:323 → 427
    PCI; PCI domain
    pfam10602
    Location:127 → 308
    RPN7; 26S proteasome subunit RPN7

  8. NM_001394759.1 → NP_001381688.1  COP9 signalosome complex subunit 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    A0A9L9PX62, B4DND6
    Related
    ENSP00000516491.1, ENST00000706670.1
    Conserved Domains (1) summary
    COG5187
    Location:235 → 533
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  9. NM_001394760.1 → NP_001381689.1  COP9 signalosome complex subunit 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:207 → 506
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  10. NM_001394761.1 → NP_001381690.1  COP9 signalosome complex subunit 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS92418.1
    UniProtKB/TrEMBL
    A8K070, B4DND6
    Related
    ENSP00000485035.1, ENST00000623761.3
    Conserved Domains (2) summary
    pfam01399
    Location:359 → 463
    PCI; PCI domain
    pfam10602
    Location:163 → 344
    RPN7; 26S proteasome subunit RPN7

  11. NM_001394762.1 → NP_001381691.1  COP9 signalosome complex subunit 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:155 → 454
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  12. NM_001394763.1 → NP_001381692.1  COP9 signalosome complex subunit 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:155 → 454
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  13. NM_001394764.1 → NP_001381693.1  COP9 signalosome complex subunit 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:155 → 453
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  14. NM_001394765.1 → NP_001381694.1  COP9 signalosome complex subunit 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:308 → 412
    PCI; PCI domain
    pfam10602
    Location:111 → 293
    RPN7; 26S proteasome subunit RPN7

  15. NM_001394766.1 → NP_001381695.1  COP9 signalosome complex subunit 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:308 → 412
    PCI; PCI domain
    pfam10602
    Location:111 → 293
    RPN7; 26S proteasome subunit RPN7

  16. NM_001394767.1 → NP_001381696.1  COP9 signalosome complex subunit 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:308 → 412
    PCI; PCI domain
    pfam10602
    Location:111 → 293
    RPN7; 26S proteasome subunit RPN7

  17. NM_001394768.1 → NP_001381697.1  COP9 signalosome complex subunit 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:307 → 411
    PCI; PCI domain
    pfam10602
    Location:111 → 292
    RPN7; 26S proteasome subunit RPN7

  18. NM_001394769.1 → NP_001381698.1  COP9 signalosome complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS82228.1
    UniProtKB/TrEMBL
    B4DND6, C9JFE4
    Conserved Domains (2) summary
    pfam01399
    Location:304 → 408
    PCI; PCI domain
    pfam10602
    Location:107 → 289
    RPN7; 26S proteasome subunit RPN7

  19. NM_001394770.1 → NP_001381699.1  COP9 signalosome complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS82228.1
    UniProtKB/TrEMBL
    B4DND6, C9JFE4
    Conserved Domains (2) summary
    pfam01399
    Location:304 → 408
    PCI; PCI domain
    pfam10602
    Location:107 → 289
    RPN7; 26S proteasome subunit RPN7

  20. NM_001394771.1 → NP_001381700.1  COP9 signalosome complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS82228.1
    UniProtKB/TrEMBL
    B4DND6, C9JFE4
    Conserved Domains (2) summary
    pfam01399
    Location:304 → 408
    PCI; PCI domain
    pfam10602
    Location:107 → 289
    RPN7; 26S proteasome subunit RPN7

  21. NM_001394772.1 → NP_001381701.1  COP9 signalosome complex subunit 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:303 → 407
    PCI; PCI domain
    pfam10602
    Location:107 → 288
    RPN7; 26S proteasome subunit RPN7

  22. NM_001394773.1 → NP_001381702.1  COP9 signalosome complex subunit 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:303 → 407
    PCI; PCI domain
    pfam10602
    Location:107 → 288
    RPN7; 26S proteasome subunit RPN7

  23. NM_001394774.1 → NP_001381703.1  COP9 signalosome complex subunit 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:167 → 439
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  24. NM_001394775.1 → NP_001381704.1  COP9 signalosome complex subunit 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:163 → 435
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  25. NM_001394776.1 → NP_001381705.1  COP9 signalosome complex subunit 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:155 → 427
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  26. NM_001394777.1 → NP_001381706.1  COP9 signalosome complex subunit 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC135056
    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (1) summary
    COG5187
    Location:167 → 418
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

  27. NM_004127.7 → NP_004118.3  COP9 signalosome complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_004118.3

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS32774.1
    UniProtKB/Swiss-Prot
    Q13098, Q8NA10, Q9BWL1
    UniProtKB/TrEMBL
    B4DND6
    Related
    ENSP00000302873.6, ENST00000306823.10
    Conserved Domains (2) summary
    pfam01399
    Location:324 → 428
    PCI; PCI domain
    pfam10602
    Location:127 → 309
    RPN7; 26S proteasome subunit RPN7

  28. NM_212492.4 → NP_997657.1  COP9 signalosome complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_997657.1

    Status: REVIEWED

    Source sequence(s)
    AC135056
    Consensus CDS
    CCDS11800.1
    UniProtKB/TrEMBL
    B4DND6
    Related
    ENSP00000376167.2, ENST00000392358.6
    Conserved Domains (2) summary
    pfam01399
    Location:360 → 464
    PCI; PCI domain
    pfam10602
    Location:163 → 345
    RPN7; 26S proteasome subunit RPN7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    82050932..82057470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435841.1 → XP_047291797.1  COP9 signalosome complex subunit 1 isoform X16

  2. XM_047435845.1 → XP_047291801.1  COP9 signalosome complex subunit 1 isoform X19

  3. XM_047435847.1 → XP_047291803.1  COP9 signalosome complex subunit 1 isoform X21

  4. XM_047435829.1 → XP_047291785.1  COP9 signalosome complex subunit 1 isoform X1

  5. XM_047435836.1 → XP_047291792.1  COP9 signalosome complex subunit 1 isoform X11

  6. XM_017024524.3 → XP_016880013.1  COP9 signalosome complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    B4DND6

  7. XM_047435837.1 → XP_047291793.1  COP9 signalosome complex subunit 1 isoform X12

  8. XM_047435830.1 → XP_047291786.1  COP9 signalosome complex subunit 1 isoform X3

  9. XM_047435832.1 → XP_047291788.1  COP9 signalosome complex subunit 1 isoform X6

  10. XM_047435839.1 → XP_047291795.1  COP9 signalosome complex subunit 1 isoform X14

  11. XM_047435846.1 → XP_047291802.1  COP9 signalosome complex subunit 1 isoform X20

  12. XM_047435850.1 → XP_047291806.1  COP9 signalosome complex subunit 1 isoform X1

  13. XM_047435851.1 → XP_047291807.1  COP9 signalosome complex subunit 1 isoform X2

  14. XM_047435855.1 → XP_047291811.1  COP9 signalosome complex subunit 1 isoform X12

  15. XM_047435854.1 → XP_047291810.1  COP9 signalosome complex subunit 1 isoform X3

  16. XM_005256350.2 → XP_005256407.1  COP9 signalosome complex subunit 1 isoform X4

    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:392 → 496
    PCI; PCI domain
    pfam10602
    Location:195 → 377
    RPN7; 26S proteasome subunit RPN7

  17. XM_047435831.1 → XP_047291787.1  COP9 signalosome complex subunit 1 isoform X5

  18. XM_005256353.2 → XP_005256410.1  COP9 signalosome complex subunit 1 isoform X8

    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:388 → 492
    PCI; PCI domain
    pfam10602
    Location:191 → 373
    RPN7; 26S proteasome subunit RPN7

  19. XM_017024525.2 → XP_016880014.1  COP9 signalosome complex subunit 1 isoform X10

    UniProtKB/TrEMBL
    B4DND6

  20. XM_047435833.1 → XP_047291789.1  COP9 signalosome complex subunit 1 isoform X7

  21. XM_047435838.1 → XP_047291794.1  COP9 signalosome complex subunit 1 isoform X13

  22. XM_047435840.1 → XP_047291796.1  COP9 signalosome complex subunit 1 isoform X15

  23. XM_047435835.1 → XP_047291791.1  COP9 signalosome complex subunit 1 isoform X9

  24. XM_047435842.1 → XP_047291798.1  COP9 signalosome complex subunit 1 isoform X17

  25. XM_047435843.1 → XP_047291799.1  COP9 signalosome complex subunit 1 isoform X18

  26. XM_047435849.1 → XP_047291805.1  COP9 signalosome complex subunit 1 isoform X1

  27. XM_047435853.1 → XP_047291809.1  COP9 signalosome complex subunit 1 isoform X3

  28. XM_017024531.3 → XP_016880020.1  COP9 signalosome complex subunit 1 isoform X6

    UniProtKB/TrEMBL
    B4DND6

  29. XM_005256359.3 → XP_005256416.1  COP9 signalosome complex subunit 1 isoform X22

    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:324 → 428
    PCI; PCI domain
    pfam10602
    Location:127 → 309
    RPN7; 26S proteasome subunit RPN7

  30. XM_047435848.1 → XP_047291804.1  COP9 signalosome complex subunit 1 isoform X23

  31. XM_005256360.5 → XP_005256417.1  COP9 signalosome complex subunit 1 isoform X24

    UniProtKB/TrEMBL
    B4DND6
    Conserved Domains (2) summary
    pfam01399
    Location:320 → 424
    PCI; PCI domain
    pfam10602
    Location:123 → 305
    RPN7; 26S proteasome subunit RPN7

  32. XM_017024527.3 → XP_016880016.1  COP9 signalosome complex subunit 1 isoform X25

    UniProtKB/TrEMBL
    B4DND6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82918090..82924628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315851.1 → XP_054171826.1  COP9 signalosome complex subunit 1 isoform X16

  2. XM_054315854.1 → XP_054171829.1  COP9 signalosome complex subunit 1 isoform X19

  3. XM_054315856.1 → XP_054171831.1  COP9 signalosome complex subunit 1 isoform X21

  4. XM_054315836.1 → XP_054171811.1  COP9 signalosome complex subunit 1 isoform X1

  5. XM_054315846.1 → XP_054171821.1  COP9 signalosome complex subunit 1 isoform X11

  6. XM_054315837.1 → XP_054171812.1  COP9 signalosome complex subunit 1 isoform X2

  7. XM_054315847.1 → XP_054171822.1  COP9 signalosome complex subunit 1 isoform X12

  8. XM_054315838.1 → XP_054171813.1  COP9 signalosome complex subunit 1 isoform X3

  9. XM_054315841.1 → XP_054171816.1  COP9 signalosome complex subunit 1 isoform X6

  10. XM_054315849.1 → XP_054171824.1  COP9 signalosome complex subunit 1 isoform X14

  11. XM_054315855.1 → XP_054171830.1  COP9 signalosome complex subunit 1 isoform X20

  12. XM_054315862.1 → XP_054171837.1  COP9 signalosome complex subunit 1 isoform X1

  13. XM_054315863.1 → XP_054171838.1  COP9 signalosome complex subunit 1 isoform X2

  14. XM_054315867.1 → XP_054171842.1  COP9 signalosome complex subunit 1 isoform X12

  15. XM_054315865.1 → XP_054171840.1  COP9 signalosome complex subunit 1 isoform X3

  16. XM_054315839.1 → XP_054171814.1  COP9 signalosome complex subunit 1 isoform X4

  17. XM_054315840.1 → XP_054171815.1  COP9 signalosome complex subunit 1 isoform X5

  18. XM_054315843.1 → XP_054171818.1  COP9 signalosome complex subunit 1 isoform X8

  19. XM_054315845.1 → XP_054171820.1  COP9 signalosome complex subunit 1 isoform X10

  20. XM_054315842.1 → XP_054171817.1  COP9 signalosome complex subunit 1 isoform X7

  21. XM_054315848.1 → XP_054171823.1  COP9 signalosome complex subunit 1 isoform X13

  22. XM_054315850.1 → XP_054171825.1  COP9 signalosome complex subunit 1 isoform X15

  23. XM_054315844.1 → XP_054171819.1  COP9 signalosome complex subunit 1 isoform X9

  24. XM_054315852.1 → XP_054171827.1  COP9 signalosome complex subunit 1 isoform X17

  25. XM_054315853.1 → XP_054171828.1  COP9 signalosome complex subunit 1 isoform X18

  26. XM_054315861.1 → XP_054171836.1  COP9 signalosome complex subunit 1 isoform X1

  27. XM_054315864.1 → XP_054171839.1  COP9 signalosome complex subunit 1 isoform X3

  28. XM_054315866.1 → XP_054171841.1  COP9 signalosome complex subunit 1 isoform X6

  29. XM_054315857.1 → XP_054171832.1  COP9 signalosome complex subunit 1 isoform X22

  30. XM_054315858.1 → XP_054171833.1  COP9 signalosome complex subunit 1 isoform X23

  31. XM_054315859.1 → XP_054171834.1  COP9 signalosome complex subunit 1 isoform X24

  32. XM_054315860.1 → XP_054171835.1  COP9 signalosome complex subunit 1 isoform X25

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13098.4 GenPept UniProtKB/Swiss-Prot:Q13098

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