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Shroom1 shroom family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287285, updated on 4-Jan-2025

Summary

Official Symbol
Shroom1provided by RGD
Official Full Name
shroom family member 1provided by RGD
Primary source
RGD:1308066
See related
EnsemblRapid:ENSRNOG00000007431 AllianceGenome:RGD:1308066
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308066
Summary
Predicted to enable actin filament binding activity and myosin II binding activity. Predicted to be involved in actin filament bundle assembly and cell morphogenesis. Predicted to be located in microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human SHROOM1 (shroom family member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 56.1), Brain (RPKM 14.0) and 6 other tissues See more
Orthologs
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Genomic context

See Shroom1 in Genome Data Viewer
Location:
10q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38121971..38134832)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (37621149..37631895)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38814420..38825159)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene liver enriched antimicrobial peptide 2 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene growth differentiation factor 9 Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene septin 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin II binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    38121971..38134832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246367.5XP_006246429.1  protein Shroom1 isoform X1

    See identical proteins and their annotated locations for XP_006246429.1

    UniProtKB/TrEMBL
    A0A8I5ZRQ2, M0RB44
    Related
    ENSRNOP00000081463.2, ENSRNOT00000113885.2
    Conserved Domains (2) summary
    pfam08687
    Location:552829
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:150273
    ASD1; Apx/Shroom domain ASD1
  2. XM_039087192.2XP_038943120.1  protein Shroom1 isoform X2

    UniProtKB/TrEMBL
    M0RB44
    Conserved Domains (2) summary
    pfam08687
    Location:552817
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:150275
    ASD1; Apx/Shroom domain ASD1