U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rhot2 ras homolog family member T2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287156, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Rhot2provided by RGD
Official Full Name
ras homolog family member T2provided by RGD
Primary source
RGD:727970
See related
EnsemblRapid:ENSRNOG00000019930 AllianceGenome:RGD:727970
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Miro2
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular homeostasis; mitochondrial outer membrane permeabilization; and mitochondrion transport along microtubule. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human RHOT2 (ras homolog family member T2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 137.3), Kidney (RPKM 132.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rhot2 in Genome Data Viewer
Location:
10q12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15363467..15369263, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14858954..14864751, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15205943..15211739, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 8 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene rhomboid like 1 Neighboring gene WD repeat domain 90 Neighboring gene MAPK regulated co-repressor interacting protein 2 Neighboring gene methyltransferase like 26 Neighboring gene transfer RNA glycine (anticodon CCC) 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Saotome M, et al. Proc Natl Acad Sci U S A, 2008 Dec 30. PMID 19098100, Free PMC Article
  2. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Fransson A, et al. J Biol Chem, 2003 Feb 21. PMID 12482879
  3. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Fransson S, et al. Biochem Biophys Res Commun, 2006 Jun 2. PMID 16630562
  4. Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase. Shan Y, et al. Cytogenet Genome Res, 2004. PMID 15218247
  5. Regulation of mitochondrial transport in neurons. Lin MY, et al. Exp Cell Res, 2015 May 15. PMID 25612908, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial outer membrane permeabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial outer membrane permeabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mitochondrial Rho GTPase 2
Names
MIRO-2
ras homolog gene family, member T2
NP_861544.1
XP_017452558.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181823.1 → NP_861544.1  mitochondrial Rho GTPase 2

    See identical proteins and their annotated locations for NP_861544.1

    Status: PROVISIONAL

    Source sequence(s)
    AY303973
    UniProtKB/Swiss-Prot
    Q7TSA0
    UniProtKB/TrEMBL
    A6HD65
    Conserved Domains (6) summary
    smart00174
    Location:7 → 169
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:414 → 593
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3 → 169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    COG1100
    Location:422 → 534
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam08355
    Location:341 → 408
    EF_assoc_1; EF hand associated
    pfam08356
    Location:221 → 301
    EF_assoc_2; EF hand associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15363467..15369263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597069.2 → XP_017452558.1  mitochondrial Rho GTPase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSA0
    UniProtKB/TrEMBL
    A6HD65
    Related
    ENSRNOP00000027083.3, ENSRNOT00000027083.7
    Conserved Domains (6) summary
    smart00174
    Location:7 → 169
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:414 → 593
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3 → 169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    COG1100
    Location:422 → 534
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam08355
    Location:341 → 408
    EF_assoc_1; EF hand associated
    pfam08356
    Location:221 → 301
    EF_assoc_2; EF hand associated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSA0.1 GenPept UniProtKB/Swiss-Prot:Q7TSA0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous