Metrn meteorin, glial cell differentiation regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Metrnprovided by RGD
Official Full Name: meteorin, glial cell differentiation regulatorprovided by RGD
Primary source: RGD:1306222
See related: AllianceGenome:RGD:1306222
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hyrac; RGD1306222
Summary: Predicted to enable hormone activity. Predicted to be involved in glial cell differentiation and positive regulation of axonogenesis. Predicted to act upstream of or within radial glial cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human METRN (meteorin, glial cell differentiation regulator). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 234.1), Kidney (RPKM 164.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (15321200..15323218, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14816684..14818702, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15164439..15166457, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metrn promotes migration of neuroblasts from subventricular zone explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism.
Title: Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.
Cellular protection afforded by meteorin is associated with normalization of neurological performance on spontaneous forelimb placing and cylinder behavioral tests.
Title: Lentiviral delivery of meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model.
Data show that Meteorin is expressed in the central nervous system both during development and in adult mice.
Title: Characterization of Meteorin--an evolutionary conserved neurotrophic factor.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: meteorin

Names: hypoxia/reoxygenation regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.