Prss30 protease, serine, 30 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss30provided by RGD
Official Full Name: protease, serine, 30provided by RGD
Primary source: RGD:735142
See related: EnsemblRapid:ENSRNOG00000033266 AllianceGenome:RGD:735142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: tmsp-1; Tmprss8
Summary: Enables serine-type endopeptidase activity and sodium channel regulator activity. Involved in proteolysis and sodium ion transport. Predicted to be located in side of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 54.5), Uterus (RPKM 18.3) and 1 other tissue See more
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Genomic context

Location:: 10q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (13511916..13519968, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13007341..13014827, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13348289..13355833, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease 30

Names: distal intestinal serine protease; transmembrane protease, serine 8 (intestinal); transmembrane serine protease 1; transmembrane serine protease 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199371.2 → NP_955403.2 serine protease 30 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P83748

Related

ENSRNOP00000037368.5, ENSRNOT00000034340.7

Conserved Domains (1) summary

cd00190
Location:31 → 269

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

13511916..13519968 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245923.5 → XP_006245985.1 serine protease 30 isoform X1

See identical proteins and their annotated locations for XP_006245985.1

UniProtKB/Swiss-Prot

P83748

Conserved Domains (1) summary

cd00190
Location:31 → 269

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_063268554.1 → XP_063124624.1 serine protease 30 isoform X2

UniProtKB/TrEMBL

A6HCP4, F1LQU8
XM_063268555.1 → XP_063124625.1 serine protease 30 isoform X2

UniProtKB/TrEMBL

A6HCP4, F1LQU8
XM_063268553.1 → XP_063124623.1 serine protease 30 isoform X1

UniProtKB/Swiss-Prot

P83748
XM_063268551.1 → XP_063124621.1 serine protease 30 isoform X1

UniProtKB/Swiss-Prot

P83748