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Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287101, updated on 27-Nov-2024

Summary

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Official Symbol
Pkmyt1provided by RGD
Official Full Name
protein kinase, membrane associated tyrosine/threonine 1provided by RGD
Primary source
RGD:1305434
See related
EnsemblRapid:ENSRNOG00000003657 AllianceGenome:RGD:1305434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305434
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Predicted to be located in Golgi apparatus; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 44.4), Thymus (RPKM 39.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pkmyt1 in Genome Data Viewer
Location:
10q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13252805..13263584)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12748221..12758995)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13061077..13072277)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene claudin 9 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene glycine rich extracellular protein 1 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene RIKEN cDNA 9530082P21 gene like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. Oh JS, et al. J Cell Biol, 2010 Jan 25. PMID 20083600, Free PMC Article
  2. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. Booher RN, et al. J Biol Chem, 1997 Aug 29. PMID 9268380
  3. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
NP_001099236.1
XP_017452548.1
XP_063124618.1
XP_063124619.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105766.1 → NP_001099236.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

    See identical proteins and their annotated locations for NP_001099236.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HCL6, B5DFC5, G3V6G8
    Conserved Domains (2) summary
    smart00220
    Location:101 → 350
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99 → 348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    13252805..13263584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597059.3 → XP_017452548.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

    UniProtKB/TrEMBL
    A6HCL6, B5DFC5, G3V6G8
    Related
    ENSRNOP00000004936.4, ENSRNOT00000004936.8
    Conserved Domains (2) summary
    smart00220
    Location:101 → 350
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99 → 348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  2. XM_063268549.1 → XP_063124619.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

  3. XM_063268548.1 → XP_063124618.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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