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Zfp689 zinc finger protein 689 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286996, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp689provided by RGD
Official Full Name
zinc finger protein 689provided by RGD
Primary source
RGD:628696
See related
EnsemblRapid:ENSRNOG00000066277 AllianceGenome:RGD:628696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hit39; Znf689
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within skeletal muscle cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human ZNF689 (zinc finger protein 689). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 30.1), Thymus (RPKM 26.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp689 in Genome Data Viewer
Location:
1q37
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191496370..191507277, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182065885..182074343, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198894000..198900364, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 688 Neighboring gene ATP synthase subunit ATP5MPL, mitochondrial-like Neighboring gene proline rich 14 Neighboring gene fibrosin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 689
Names
transcription factor HIT-39
zinc finger protein HIT-39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173330.2 → NP_775452.1  zinc finger protein 689

    See identical proteins and their annotated locations for NP_775452.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q99PJ7
    UniProtKB/TrEMBL
    B5DEF2
    Related
    ENSRNOP00000103030.1, ENSRNOT00000167283.1
    Conserved Domains (5) summary
    smart00349
    Location:29 → 88
    KRAB; krueppel associated box
    COG5048
    Location:159 → 466
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:29 → 68
    KRAB; KRAB box
    pfam13465
    Location:303 → 328
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191496370..191507277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102767.2 → XP_038958695.1  zinc finger protein 689 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A643
    Related
    ENSRNOP00000024969.5, ENSRNOT00000024969.9
    Conserved Domains (3) summary
    smart00349
    Location:29 → 97
    KRAB; krueppel associated box
    COG5048
    Location:121 → 428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:225 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PJ7.1 GenPept UniProtKB/Swiss-Prot:Q99PJ7

Gene LinkOut

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