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Chst15 carbohydrate sulfotransferase 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286974, updated on 27-Nov-2024

Summary

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Official Symbol
Chst15provided by RGD
Official Full Name
carbohydrate sulfotransferase 15provided by RGD
Primary source
RGD:628881
See related
EnsemblRapid:ENSRNOG00000016267 AllianceGenome:RGD:628881
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GalNAc4S6ST; Galnac4s-6st
Summary
Predicted to enable 3'-phosphoadenosine 5'-phosphosulfate binding activity and N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Predicted to be involved in hexose biosynthetic process. Predicted to be located in Golgi membrane. Orthologous to human CHST15 (carbohydrate sulfotransferase 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 97.4), Lung (RPKM 60.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chst15 in Genome Data Viewer
Location:
1q41
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (196458978..196540088, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187028860..187107908, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204243396..204328960, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase X (M14 family), member 2 Neighboring gene ribosomal protein S27, pseudogene 7 Neighboring gene uncharacterized LOC102551752 Neighboring gene uncharacterized LOC134485184 Neighboring gene transfer RNA alanine (anticodon AGC) 75

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition. Karumbaiah L, et al. Glia, 2011 Jun. PMID 21456043, Free PMC Article
  2. Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene. Ohtake S, et al. J Biol Chem, 2001 Nov 23. PMID 11572857
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93074

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding IEA
Inferred from Electronic Annotation
more info
  
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in hexose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hexose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hexose biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 15
Names
B cell RAG associated protein
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
NP_775432.3
XP_006230492.1
XP_006230493.1
XP_006230495.1
XP_017444335.1
XP_038958651.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173310.3 → NP_775432.3  carbohydrate sulfotransferase 15

    See identical proteins and their annotated locations for NP_775432.3

    Status: PROVISIONAL

    Source sequence(s)
    AB086953
    UniProtKB/Swiss-Prot
    Q5U363, Q8CHI9
    UniProtKB/TrEMBL
    A0A8I6G6L4
    Related
    ENSRNOP00000022157.5, ENSRNOT00000022157.9
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    196458978..196540088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230430.5 → XP_006230492.1  carbohydrate sulfotransferase 15 isoform X1

    See identical proteins and their annotated locations for XP_006230492.1

    UniProtKB/TrEMBL
    A0A8I6G6L4, A6HWY1, G3V838
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

  2. XM_006230433.5 → XP_006230495.1  carbohydrate sulfotransferase 15 isoform X1

    See identical proteins and their annotated locations for XP_006230495.1

    UniProtKB/TrEMBL
    A0A8I6G6L4, A6HWY1, G3V838
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

  3. XM_006230431.5 → XP_006230493.1  carbohydrate sulfotransferase 15 isoform X1

    See identical proteins and their annotated locations for XP_006230493.1

    UniProtKB/TrEMBL
    A0A8I6G6L4, A6HWY1, G3V838
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

  4. XM_039102723.2 → XP_038958651.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G6L4, A6HWY1, G3V838
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

  5. XM_017588846.3 → XP_017444335.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G6L4, A6HWY1, G3V838
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHI9.1 GenPept UniProtKB/Swiss-Prot:Q8CHI9

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