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UTS2R urotensin 2 receptor [ Homo sapiens (human) ]

Gene ID: 2837, updated on 27-Nov-2024

Summary

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Official Symbol
UTS2Rprovided by HGNC
Official Full Name
urotensin 2 receptorprovided by HGNC
Primary source
HGNC:HGNC:4468
See related
Ensembl:ENSG00000181408 MIM:600896; AllianceGenome:HGNC:4468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UTR; UTR2; GPR14; UR-2-R
Summary
Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See UTS2R in Genome Data Viewer
Location:
17q25.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82371765..82377458)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (83240931..83246624)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80329641..80335334)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80282821-80283426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80283427-80284032 Neighboring gene secreted and transmembrane 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80290146-80290948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80302606-80303141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13005 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:80309262-80309440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80309821-80310697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80313765-80314700 Neighboring gene Sharpr-MPRA regulatory region 9771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80320818-80321596 Neighboring gene testis expressed 19 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80334527-80335396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80337379-80337880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80337881-80338380 Neighboring gene uncharacterized LOC124904092 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80343201-80343886 Neighboring gene uncharacterized LOC124904090 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80357274-80357880

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Urantide conformation and interaction with the urotensin-II receptor. Brancaccio D, et al. Arch Pharm (Weinheim), 2014 Mar. PMID 24357333
  2. Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands. Nassour H, et al. J Biol Chem, 2021 Sep. PMID 34389356, Free PMC Article
  3. Solution structure of urotensin-II receptor extracellular loop III and characterization of its interaction with urotensin-II. Boivin S, et al. Peptides, 2008 May. PMID 18423797
  4. Urotensin II: a novel target in human corpus cavernosum. d'Emmanuele di Villa Bianca R, et al. J Sex Med, 2010 May. PMID 19788716
  5. Three-dimensional model of the human urotensin-II receptor: docking of human urotensin-II and nonpeptide antagonists in the binding site and comparison with an antagonist pharmacophore model. Lescot E, et al. Proteins, 2008 Oct. PMID 18409194

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands.
    Title: Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands.
  2. Urotensin II receptor expression in patients with ulcerative colitis: a pilot study.
    Title: Urotensin II receptor expression in patients with ulcerative colitis: a pilot study.
  3. Novel Mutations in UTS2R are Associated with Adolescent Idiopathic Scoliosis in the Chinese Population.
    Title: Novel Mutations in UTS2R are Associated with Adolescent Idiopathic Scoliosis in the Chinese Population.
  4. ligand-induced activation of the chemokine receptor CXCR4 and the urotensin 2 receptor UTS2R, triggers a marked reduction in the biogenesis of autophagosomes.
    Title: Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.
  5. The role of Urotensin-II receptor in vasoconstriction and in the development of digestive tract cancers
    Title: Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors.
  6. UII/GPR14 signaling was involved in the DSS-induced colonic inflammation and its inhibition may serve as a potential therapeutic target, which may be associated with the NF-kappaB signaling pathway.
    Title: UII/GPR14 is involved in NF-κB-mediated colonic inflammation in vivo and in vitro.
  7. UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
    Title: Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
  8. Urotensin II can induce the proliferation of BEL-7402 cells via the urotensin receptor mediated PKC/ERK/p38 MAPK signaling pathways.
    Title: Up-regulation of urotensin II and its receptor contributes to human hepatocellular carcinoma growth via activation of the PKC, ERK1/2, and p38 MAPK signaling pathways.
  9. Report interaction of urantide with urotensin II receptor.
    Title: Urantide conformation and interaction with the urotensin-II receptor.
  10. UTR protein and mRNA levels were increased in colon cancer cell lines and in colon adenoma and adenocarcinoma. UTR appears to be involved in the regulation of colon cancer cell invasion and motility.
    Title: Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables urotensin II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in blood circulation TAS
Traceable Author Statement
more info
 PubMed 
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
urotensin-2 receptor
Names
G-protein coupled receptor 14
UR-II-R
urotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381897.1 → NP_001368826.1  urotensin-2 receptor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC132938
    Consensus CDS
    CCDS11810.1
    UniProtKB/Swiss-Prot
    B2RMV8, Q9UKP6
    Conserved Domains (1) summary
    cd14999
    Location:53 → 326
    7tmA_UII-R; urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_018949.3 → NP_061822.1  urotensin-2 receptor

    See identical proteins and their annotated locations for NP_061822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC132938
    Consensus CDS
    CCDS11810.1
    UniProtKB/Swiss-Prot
    B2RMV8, Q9UKP6
    Related
    ENSP00000323516.2, ENST00000313135.5
    Conserved Domains (1) summary
    cd14999
    Location:53 → 326
    7tmA_UII-R; urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    82371765..82377458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    83240931..83246624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UKP6.1 GenPept UniProtKB/Swiss-Prot:Q9UKP6

Gene LinkOut

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