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MMP15 matrix metallopeptidase 15 [ Bos taurus (domestic cattle) ]

Gene ID: 282887, updated on 1-Jan-2025

Summary

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Official Symbol
MMP15provided by VGNC
Official Full Name
matrix metallopeptidase 15provided by VGNC
Primary source
VGNC:VGNC:31520
See related
BGD:BT11142; Ensembl:ENSBTAG00000012919
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See MMP15 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (25939947..25960720)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 319 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1 Neighboring gene cilia and flagella associated protein 20 Neighboring gene casein kinase 2 alpha 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. Balcerzak D, et al. J Anim Sci, 2001 Jan. PMID 11204721
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
matrix metalloproteinase-15
Names
matrix metallopeptidase 15 (membrane-inserted)
matrix metalloproteinase 15 (membrane-inserted)
NP_001178363.1
XP_010812723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191434.2 → NP_001178363.1  matrix metalloproteinase-15 precursor

    See identical proteins and their annotated locations for NP_001178363.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000018
    UniProtKB/TrEMBL
    A0AAA9T2A9, F1MHG1
    Related
    ENSBTAP00000017168.5, ENSBTAT00000017168.6
    Conserved Domains (5) summary
    cd00094
    Location:367 → 559
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:138 → 304
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:138 → 304
    Peptidase_M10; Matrixin
    pfam01471
    Location:51 → 106
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:650 → 675
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    25939947..25960720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010814421.4 → XP_010812723.1  matrix metalloproteinase-15 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MID0, A0AAA9T2A9
    Related
    ENSBTAP00000071021.1, ENSBTAT00000076510.2
    Conserved Domains (4) summary
    cd00094
    Location:318 → 510
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:89 → 255
    Peptidase_M10; Matrixin
    pfam01471
    Location:3 → 57
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:600 → 626
    DUF3377; Domain of unknown function (DUF3377)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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