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SOST sclerostin [ Bos taurus (domestic cattle) ]

Gene ID: 282880, updated on 27-Dec-2024

Summary

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Official Symbol
SOSTprovided by VGNC
Official Full Name
sclerostinprovided by VGNC
Primary source
VGNC:VGNC:35135
See related
BGD:BT12928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SOST in Genome Data Viewer
Location:
chromosome: 19
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (43644356..43649247, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene mesenchyme homeobox 1 Neighboring gene uncharacterized LOC132342987 Neighboring gene dual specificity phosphatase 3 Neighboring gene CFAP97 domain containing 1 Neighboring gene MAGUK p55 scaffold protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Brunkow ME, et al. Am J Hum Genet, 2001 Mar. PMID 11179006, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables BMP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sclerostin
Names
sclerosteosis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166514.3 → NP_001159986.1  sclerostin precursor

    See identical proteins and their annotated locations for NP_001159986.1

    Status: VALIDATED

    Source sequence(s)
    AF326738, NKLS02000019
    UniProtKB/Swiss-Prot
    Q9BG79
    Conserved Domains (1) summary
    cl21545
    Location:1 → 209
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43644356..43649247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BG79.2 GenPept UniProtKB/Swiss-Prot:Q9BG79

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials