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Aip aryl-hydrocarbon receptor-interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 282827, updated on 4-Jan-2025

Summary

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Official Symbol
Aipprovided by RGD
Official Full Name
aryl-hydrocarbon receptor-interacting proteinprovided by RGD
Primary source
RGD:628619
See related
EnsemblRapid:ENSRNOG00000022289 AllianceGenome:RGD:628619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
XAP2
Summary
Enables enzyme binding activity. Involved in protein kinase A signaling. Predicted to be located in cytosol and plasma membrane. Predicted to be part of aryl hydrocarbon receptor complex. Human ortholog(s) of this gene implicated in pituitary adenoma 1. Orthologous to human AIP (aryl hydrocarbon receptor interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 116.4), Lung (RPKM 106.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aip in Genome Data Viewer
Location:
1q43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210837473..210848691, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201408002..201419220, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219361859..219373924, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 2 associated protein 2 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene transmembrane protein 134 Neighboring gene calcium binding protein 4 Neighboring gene G protein-coupled receptor 152

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aip regulates cAMP signalling and GH secretion in GH3 cells. Formosa R, et al. Endocr Relat Cancer, 2013 Aug. PMID 23702468
  2. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line. Fukuda T, et al. PLoS One, 2016. PMID 27706259, Free PMC Article
  3. Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines. Pollenz RS, et al. J Biol Chem, 2005 Sep 30. PMID 16085934
  4. RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas. Garcia-Rendueles AR, et al. Oncogene, 2021 Nov. PMID 34588620, Free PMC Article
  5. The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability. Vargiolu M, et al. J Clin Endocrinol Metab, 2009 Jul. PMID 19366855

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas.
    Title: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas.
  2. Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation.
    Title: Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.
  3. Aip regulates cAMP signalling and growth hormone secretion in GH3 cells.
    Title: Aip regulates cAMP signalling and GH secretion in GH3 cells.
  4. results suggest that XAP2 functionally interacts with PDE4A5 in cells
    Title: Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
  5. The role of Xap2 and C-terminal hsp-70 interacting protein on the endogenous Ah receptors expressed in rat cell lines was determined.
    Title: Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GAF domain binding ISO
Inferred from Sequence Orthology
more info
  
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein kinase A signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein maturation by protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation by protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of aryl hydrocarbon receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AH receptor-interacting protein
Names
HBV-X associated protein
immunophilin XAP2
NP_758830.2
XP_006230762.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172327.3 → NP_758830.2  AH receptor-interacting protein

    See identical proteins and their annotated locations for NP_758830.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5FWY5, Q8CGW7
    UniProtKB/TrEMBL
    A0A8L2PZ29, A6HYT6
    Related
    ENSRNOP00000075162.1, ENSRNOT00000091542.3
    Conserved Domains (2) summary
    sd00006
    Location:183 → 225
    TPR; TPR repeat [structural motif]
    cl19519
    Location:29 → 90
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210837473..210848691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230700.5 → XP_006230762.1  AH receptor-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006230762.1

    UniProtKB/Swiss-Prot
    Q5FWY5, Q8CGW7
    UniProtKB/TrEMBL
    A0A8L2PZ29, A6HYT6
    Conserved Domains (2) summary
    sd00006
    Location:183 → 225
    TPR; TPR repeat [structural motif]
    cl19519
    Location:29 → 90
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWY5.1 GenPept UniProtKB/Swiss-Prot:Q5FWY5

Gene LinkOut

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