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HMGB1 high mobility group box 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282691, updated on 27-Dec-2024

Summary

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Official Symbol
HMGB1provided by VGNC
Official Full Name
high mobility group box 1provided by VGNC
Primary source
VGNC:VGNC:53816
See related
BGD:BT10780; Ensembl:ENSBTAG00000018103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See HMGB1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (30209575..30334067)

Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene transfer RNA asparagine (anticodon GUU) Neighboring gene ubiquitin specific peptidase like 1 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene uncharacterized LOC112449053 Neighboring gene uncharacterized LOC132346756

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture. Fan W, et al. Virulence, 2021 Dec. PMID 34008469, Free PMC Article
  2. The primary structures of non-histone chromosomal proteins HMG 1 and 2. Walker JM, et al. FEBS Lett, 1980 Dec 29. PMID 7202717
  3. HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent. Kriatchko AN, et al. BMC Mol Biol, 2008 Apr 1. PMID 18380906, Free PMC Article
  4. High mobility group box-1 (HMGB-1) in osteoarthritic cartilage. Heinola T, et al. Clin Exp Rheumatol, 2010 Jul-Aug. PMID 20659415
  5. [Interaction between non-histone chromatin protein HMGB1 and linker histone H1]. Fonin AV, et al. Tsitologiia, 2010. PMID 21268854

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture.
    Title: β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture.
  2. Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
    Title: Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
  3. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
    Title: Synergistic effect of high-mobility group box-1 and lipopolysaccharide on cytokine induction in bovine peripheral blood mononuclear cells.
  4. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis.
    Title: One SNP in the 3'-UTR of HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis in dairy cattle.
  5. The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy.
    Title: [The structure of the complexes of DNA with chromosomal protein HMGB1 and histone H1 in the presence of manganese ions. I. Circular dicroism spectroscopy].
  6. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
    Title: [Conformational peculiarities of nuclear protein HMGB1 and specificity of its interaction with DNA].
  7. Interaction between non-histone chromatin protein HMGB1 and linker histone H1
    Title: [Interaction between non-histone chromatin protein HMGB1 and linker histone H1].
  8. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
    Title: High mobility group box-1 (HMGB-1) in osteoarthritic cartilage.
  9. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin.
    Title: Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.
  10. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
    Title: Micromechanical analysis of the binding of DNA-bending proteins HMGB1, NHP6A, and HU reveals their ability to form highly stable DNA-protein complexes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding, bending IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high mobility group protein B1
Names
HMG-1
high mobility group protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176612.1 → NP_788785.1  high mobility group protein B1

    See identical proteins and their annotated locations for NP_788785.1

    Status: PROVISIONAL

    Source sequence(s)
    X12796
    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39
    Related
    ENSBTAP00000024094.3, ENSBTAT00000024094.5
    Conserved Domains (2) summary
    pfam00505
    Location:95 → 162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:6 → 78
    HMG_box_2; HMG-box domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    30209575..30334067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059891959.1 → XP_059747942.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  2. XM_059891962.1 → XP_059747945.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  3. XM_059891965.1 → XP_059747948.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  4. XM_059891963.1 → XP_059747946.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  5. XM_059891961.1 → XP_059747944.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  6. XM_059891967.1 → XP_059747950.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  7. XM_059891960.1 → XP_059747943.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  8. XM_059891966.1 → XP_059747949.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39

  9. XM_059891964.1 → XP_059747947.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    A5D9G8, P10103, Q3ZC39
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10103.3 GenPept UniProtKB/Swiss-Prot:P10103

Gene LinkOut

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