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PPP2R3B protein phosphatase 2 regulatory subunit B''beta [ Homo sapiens (human) ]

Gene ID: 28227, updated on 27-Nov-2024

Summary

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Official Symbol
PPP2R3Bprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B''betaprovided by HGNC
Primary source
HGNC:HGNC:13417
See related
Ensembl:ENSG00000167393 Ensembl:ENSG00000292327 MIM:300339; AllianceGenome:HGNC:13417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR48; PR70; NYREN8; PPP2R3L; PPP2R3LY
Summary
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
Expression
Broad expression in heart (RPKM 9.0), testis (RPKM 5.0) and 23 other tissues See more
Orthologs
all
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Genomic context

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See PPP2R3B in Genome Data Viewer
Location:
X;Y
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (333933..386907, complement)
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (333933..386907, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (164977..218172, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (168543..224805, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (294668..347642, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (244668..297642, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:323668-324173 and GRCh37_chrY:273658-274173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:274174-274688 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:333708-333890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:335885-336775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:357819-358704 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:389565-389736 Neighboring gene uncharacterized LOC102724521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:396687-397186 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chrX:406609-407442 and GRCh37_chrY:356916-357447 Neighboring gene CNE-5 enhancer upstream of SHOX Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:461079-461645 Neighboring gene CNE-3 enhancer upstream of SHOX Neighboring gene fatty acid binding protein 5 pseudogene 13

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:323668-324173 and GRCh37_chrY:273658-274173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:274174-274688 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:333708-333890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:335885-336775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:357819-358704 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:389565-389736 Neighboring gene uncharacterized LOC102724521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:396687-397186 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chrX:406609-407442 and GRCh37_chrY:356916-357447 Neighboring gene CNE-5 enhancer upstream of SHOX Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:461079-461645 Neighboring gene CNE-3 enhancer upstream of SHOX Neighboring gene fatty acid binding protein 5 pseudogene 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. Stevens I, et al. Eur J Biochem, 2003 Jan. PMID 12605688
  2. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. Schiebel K, et al. Cytogenet Cell Genet, 2000. PMID 11173861
  3. Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A. Dovega R, et al. PLoS One, 2014. PMID 25007185, Free PMC Article
  4. Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype. Polubothu S, et al. Genet Med, 2021 Sep. PMID 34145395, Free PMC Article
  5. Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS). Yokoyama N, et al. Oncogene, 2001 Sep 20. PMID 11593413

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ60425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Names
NY-REN-8 antigen
protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta
protein phosphatase 2, regulatory subunit B'', beta
serine/threonine protein phosphatase 2A, 48kDa regulatory subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013257.1 RefSeqGene

    Range
    4986..57960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013239.5 → NP_037371.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

    See identical proteins and their annotated locations for NP_037371.2

    Status: REVIEWED

    Source sequence(s)
    AL954664, BK000521, BM666129, BM715684, DA061573
    Consensus CDS
    CCDS14104.1
    UniProtKB/Swiss-Prot
    Q6P4G9, Q7RTT1, Q96H01, Q9Y5P8
    UniProtKB/TrEMBL
    A0A0G2JN52, A0A0G2JNR6
    Related
    ENSP00000375080.3, ENSP00000518592.1, ENST00000390665.9, ENST00000711115.1
    Conserved Domains (1) summary
    pfam13499
    Location:319 → 417
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    333933..386907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442006.1 → XP_047297962.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

  2. XM_047442001.1 → XP_047297957.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

  3. XM_047442004.1 → XP_047297960.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  4. XM_047442005.1 → XP_047297961.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  5. XM_047442002.1 → XP_047297958.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

  6. XM_047442003.1 → XP_047297959.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  7. XM_011546177.4 → XP_011544479.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011544479.1

    UniProtKB/TrEMBL
    A0A0G2JN52, A0A0G2JNR6
    Conserved Domains (1) summary
    pfam13499
    Location:319 → 417
    EF-hand_7; EF-hand domain pair

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    333933..386907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442728.1 → XP_047298684.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

  2. XM_047442723.1 → XP_047298679.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

  3. XM_047442726.1 → XP_047298682.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  4. XM_047442727.1 → XP_047298683.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  5. XM_047442724.1 → XP_047298680.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

  6. XM_047442725.1 → XP_047298681.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  7. XM_011545630.4 → XP_011543932.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011543932.1

    UniProtKB/TrEMBL
    A0A0G2JN52, A0A0G2JNR6
    Conserved Domains (1) summary
    pfam13499
    Location:319 → 417
    EF-hand_7; EF-hand domain pair

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187634.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    17129..70303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442890.1 → XP_047298846.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187667.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    6694..59443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442957.1 → XP_047298913.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X6

  2. XM_047442953.1 → XP_047298909.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

  3. XM_047442959.1 → XP_047298915.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  4. XM_047442960.1 → XP_047298916.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

  5. XM_047442954.1 → XP_047298910.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

  6. XM_047442958.1 → XP_047298914.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  7. XM_047442956.1 → XP_047298912.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    164977..218172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326861.1 → XP_054182836.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X7

  2. XM_054326865.1 → XP_054182840.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

  3. XM_054326858.1 → XP_054182833.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

  4. XM_054326863.1 → XP_054182838.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  5. XM_054326864.1 → XP_054182839.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  6. XM_054326859.1 → XP_054182834.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

  7. XM_054326862.1 → XP_054182837.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  8. XM_054326860.1 → XP_054182835.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

  9. XM_054326866.1 → XP_054182841.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    168543..224805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328277.1 → XP_054184252.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X10

  2. XM_054328271.1 → XP_054184246.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

  3. XM_054328275.1 → XP_054184250.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  4. XM_054328276.1 → XP_054184251.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  5. XM_054328272.1 → XP_054184247.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X9

  6. XM_054328274.1 → XP_054184249.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  7. XM_054328273.1 → XP_054184248.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199326.1: Suppressed sequence

    Description
    NM_199326.1: This RefSeq was permanently suppressed because the CDS was partial, and the transcript retains intronic sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5P8.2 GenPept UniProtKB/Swiss-Prot:Q9Y5P8

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