IGFBP1 insulin like growth factor binding protein 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: IGFBP1provided by VGNC
Official Full Name: insulin like growth factor binding protein 1provided by VGNC
Primary source: VGNC:VGNC:30083
See related: Ensembl:ENSBTAG00000046768
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (76131285..76136236, complement)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus elongation by stimulating migration and attachment of the trophectoderm
Title: Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation.
Allantoic fluid levels of IGFBP-1 were increased in nuclear transfer pregnancies
Title: Insulin-like growth factor-I and binding proteins 1, 2, and 3 in bovine nuclear transfer pregnancies.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables insulin-like growth factor I binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor II binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 1

Names: IBP-1; IGF-binding protein 1; IGFBP-1; bIGFBP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174554.3 → NP_776979.2 insulin-like growth factor-binding protein 1 precursor

See identical proteins and their annotated locations for NP_776979.2

Status: PROVISIONAL

Source sequence(s)

BC111197

UniProtKB/Swiss-Prot

P24591, Q2T9Z3

UniProtKB/TrEMBL

A0AAA9RVZ1

Related

ENSBTAP00000055280.1, ENSBTAT00000064194.3

Conserved Domains (2) summary

smart00121
Location:30 → 107

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:180 → 255

Thyroglobulin_1; Thyroglobulin type-1 repeat