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GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 [ Bos taurus (domestic cattle) ]

Gene ID: 282240, updated on 1-Jan-2025

Summary

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Official Symbol
GABRG2provided by VGNC
Official Full Name
gamma-aminobutyric acid type A receptor subunit gamma2provided by VGNC
Primary source
VGNC:VGNC:29200
See related
BGD:BT11070; Ensembl:ENSBTAG00000010251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See GABRG2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (73772128..73901451)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha6 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha1 Neighboring gene uncharacterized LOC132345836 Neighboring gene hyaluronan mediated motility receptor-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site. Whiting P, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 1702226, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GABA-gated chloride ion channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables benzodiazepine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables inhibitory extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of GABA-A receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit gamma-2
Names
GABA(A) receptor subunit gamma-2
GABAAR subunit gamma-2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
gamma-aminobutyric acid type A receptor gamma2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174545.1 → NP_776970.1  gamma-aminobutyric acid receptor subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_776970.1

    Status: PROVISIONAL

    Source sequence(s)
    M55563
    UniProtKB/Swiss-Prot
    P22300
    UniProtKB/TrEMBL
    G3MYR4
    Related
    ENSBTAP00000013543.3, ENSBTAT00000013543.4
    Conserved Domains (3) summary
    TIGR00860
    Location:69 → 472
    LIC; Cation transporter family protein
    pfam02931
    Location:69 → 272
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:279 → 469
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    73772128..73901451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005209697.5 → XP_005209754.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform X1

    See identical proteins and their annotated locations for XP_005209754.1

    UniProtKB/TrEMBL
    A0AAA9TRW3, G3MYR4
    Related
    ENSBTAP00000099775.1, ENSBTAT00000104869.1
    Conserved Domains (1) summary
    cl27321
    Location:69 → 464
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22300.1 GenPept UniProtKB/Swiss-Prot:P22300

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials