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BCKDHB branched chain keto acid dehydrogenase E1 subunit beta [ Bos taurus (domestic cattle) ]

Gene ID: 282150, updated on 27-Dec-2024

Summary

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Official Symbol
BCKDHBprovided by VGNC
Official Full Name
branched chain keto acid dehydrogenase E1 subunit betaprovided by VGNC
Primary source
VGNC:VGNC:97245
See related
BGD:BT23846; Ensembl:ENSBTAG00000012096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See BCKDHB in Genome Data Viewer
Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (19804082..20074755)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346203 Neighboring gene ELOVL fatty acid elongase 4 Neighboring gene TTK protein kinase Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene uncharacterized LOC132346204 Neighboring gene uncharacterized LOC104972971

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a complementary DNA clone coding for the E1 beta subunit of the bovine branched-chain alpha-ketoacid dehydrogenase complex: complete amino acid sequence of the precursor protein and its proteolytic processing. Nobukuni Y, et al. Biochemistry, 1990 Feb 6. PMID 2322554
  2. Cloning and expression in Escherichia coli of mature E1 beta subunit of bovine mitochondrial branched-chain alpha-keto acid dehydrogenase complex. Mapping of the E1 beta-binding region on E2. Wynn RM, et al. J Biol Chem, 1992 Jan 25. PMID 1730724
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC140675

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in branched-chain amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Names
BCKDE1B
BCKDH E1-beta
branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)
branched-chain alpha-keto acid dehydrogenase E1 component beta chain
NP_776932.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174507.2 → NP_776932.1  2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_776932.1

    Status: PROVISIONAL

    Source sequence(s)
    M33323
    UniProtKB/TrEMBL
    A0AAA9T938
    Related
    ENSBTAP00000016044.6, ENSBTAT00000016044.7
    Conserved Domains (3) summary
    cd07036
    Location:75 → 241
    TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
    PTZ00182
    Location:66 → 390
    PTZ00182; 3-methyl-2-oxobutanate dehydrogenase; Provisional
    pfam02780
    Location:262 → 381
    Transketolase_C; Transketolase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    19804082..20074755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21839.2 GenPept UniProtKB/Swiss-Prot:P21839

Gene LinkOut

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