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ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282144, updated on 1-Jan-2025

Summary

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Official Symbol
ATP1A1provided by VGNC
Official Full Name
ATPase Na+/K+ transporting subunit alpha 1provided by VGNC
Primary source
VGNC:VGNC:26282
See related
BGD:BT11164; Ensembl:ENSBTAG00000001246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ATP1A1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (26886570..26918899, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 3 Neighboring gene CD58 molecule Neighboring gene uncharacterized LOC132344852 Neighboring gene uncharacterized LOC104971541

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells. Mavrogonatou E, et al. J Cell Physiol, 2015 Dec. PMID 25967398
  2. Na/K-ATPase regulates bovine sperm capacitation through raft- and non-raft-mediated signaling mechanisms. Rajamanickam GD, et al. Mol Reprod Dev, 2017 Nov. PMID 28833817
  3. Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle. Liu YX, et al. Genet Mol Res, 2012 Mar 16. PMID 22535401
  4. Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle. Liu YX, et al. Genet Mol Res, 2010 May 11. PMID 20467982
  5. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. Feschenko MS, et al. J Neurosci, 2003 Mar 15. PMID 12657675, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest ATP1A1 has a central role in the osmoregulatory response of nucleus pulposus cells.
    Title: Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.
  2. The ATP1A1 gene polymorphism has potential as a marker for mastitis resistance in dairy cattle.
    Title: Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle.
  3. The polymorphisms within the coding region of bovine ATP1A1 gene, were analyzed.
    Title: A novel SNP of the ATP1A1 gene is associated with heat tolerance traits in dairy cows.
  4. ATP1A1 gene polymorphism has a role in heat tolerance traits in dairy cattle
    Title: Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type sodium:potassium-exchanging transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of sodium:potassium-exchanging ATPase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium/potassium-transporting ATPase subunit alpha-1
Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide
Na(+)/K(+) ATPase alpha-1 subunit
sodium pump subunit alpha-1
NP_001070266.1
XP_059737690.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076798.1 → NP_001070266.1  sodium/potassium-transporting ATPase subunit alpha-1

    See identical proteins and their annotated locations for NP_001070266.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123864
    UniProtKB/Swiss-Prot
    Q08DA1
    UniProtKB/TrEMBL
    F1MI32
    Related
    ENSBTAP00000074408.1, ENSBTAT00000085581.2
    Conserved Domains (6) summary
    smart00831
    Location:38 → 112
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:604 → 750
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:25 → 1021
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:132 → 363
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:797 → 1006
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:425 → 519
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26886570..26918899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059881707.1 → XP_059737690.1  sodium/potassium-transporting ATPase subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9RXW7, F1MI32
    Related
    ENSBTAP00000077424.1, ENSBTAT00000118359.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08DA1.1 GenPept UniProtKB/Swiss-Prot:Q08DA1

Gene LinkOut

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