PTGS1 prostaglandin-endoperoxide synthase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PTGS1provided by VGNC
Official Full Name: prostaglandin-endoperoxide synthase 1provided by VGNC
Primary source: VGNC:VGNC:33511
See related: BGD:BT27813; Ensembl:ENSBTAG00000006716
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (93236344..93262105)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle
Title: Expression of cyclooxygenases 1 and 2 and prostaglandin E synthase in bovine endometrial tissue during the estrous cycle.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cyclooxygenase pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prostaglandin G/H synthase 1

Names: COX-1; PGH synthase 1; PGHS-1; PHS 1; cyclooxygenase-1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 1

NP_001098793.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105323.1 → NP_001098793.1 prostaglandin G/H synthase 1 precursor

See identical proteins and their annotated locations for NP_001098793.1

Status: PROVISIONAL

Source sequence(s)

BC134517

UniProtKB/Swiss-Prot

A7YWD4, O62664

UniProtKB/TrEMBL

A0AAA9S5R7

Related

ENSBTAP00070025291.1, ENSBTAT00070042358.1

Conserved Domains (2) summary

cd09816
Location:90 → 576

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:33 → 70

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...