LTBP2 latent transforming growth factor beta binding protein 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LTBP2provided by VGNC
Official Full Name: latent transforming growth factor beta binding protein 2provided by VGNC
Primary source: VGNC:VGNC:31072
See related: BGD:BT29709; Ensembl:ENSBTAG00000021957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	10	NC_037337.1 (85788955..85899067, complement)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta binding proteins affecting TGFbeta bioavailability in the ovary.
Title: Fibrillins and latent TGFbeta binding proteins in bovine ovaries of offspring following high or low protein diets during pregnancy of dams.
These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers.
Title: Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly.

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General gene information

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Markers

MARC_5225-5226:996690153:1 (e-PCR)
- UniSTS:269466

LTBP2 (e-PCR)
- UniSTS:278700

MARC1177-1178 (e-PCR)
- UniSTS:207072

MARC_1177-1178:1044391788:1 (e-PCR)
- UniSTS:207072

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: latent-transforming growth factor beta-binding protein 2

Names: LTBP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174385.2 → NP_776810.1 latent-transforming growth factor beta-binding protein 2

See identical proteins and their annotated locations for NP_776810.1

Status: PROVISIONAL

Source sequence(s)

U35363

UniProtKB/TrEMBL

F1MF86

Related

ENSBTAP00000029274.3, ENSBTAT00000029274.4

Conserved Domains (4) summary

smart00179
Location:1043 → 1073

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:1000 → 1034

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00683
Location:792 → 828

TB; TB domain

pfam07645
Location:1206 → 1246

EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

Range

85788955..85899067 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059890222.1 → XP_059746205.1 latent-transforming growth factor beta-binding protein 2 isoform X1

UniProtKB/TrEMBL

F1MF86
XM_059890225.1 → XP_059746208.1 latent-transforming growth factor beta-binding protein 2 isoform X3

UniProtKB/TrEMBL

F1MF86
XM_059890224.1 → XP_059746207.1 latent-transforming growth factor beta-binding protein 2 isoform X2

UniProtKB/TrEMBL

F1MF86