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HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [ Bos taurus (domestic cattle) ]

Gene ID: 281810, updated on 1-Jan-2025

Summary

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Official Symbol
HADHAprovided by VGNC
Official Full Name
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:49553
See related
BGD:BT12120; Ensembl:ENSBTAG00000015038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See HADHA in Genome Data Viewer
Location:
chromosome: 11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (73256631..73298914)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F3 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC132346607 Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene RAB10, member RAS oncogene family Neighboring gene transfer RNA cysteine (anticodon ACA)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Identification and characterization of an intracellular protein complex that binds fibroblast growth factor-2 in bovine brain. Chevet E, et al. Biochem J, 1999 Aug 1. PMID 10417336, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC128917

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
trifunctional enzyme subunit alpha, mitochondrial
Names
dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit hydroxyacyl-Coenzyme A
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
NP_776760.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174335.3 → NP_776760.2  trifunctional enzyme subunit alpha, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    NKLS02000011
    Related
    ENSBTAP00000020020.3, ENSBTAT00000020020.4

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    73256631..73298914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials