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GHRHR growth hormone releasing hormone receptor [ Bos taurus (domestic cattle) ]

Gene ID: 281782, updated on 27-Dec-2024

Summary

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Official Symbol
GHRHRprovided by VGNC
Official Full Name
growth hormone releasing hormone receptorprovided by VGNC
Primary source
VGNC:VGNC:29350
See related
BGD:BT10946; Ensembl:ENSBTAG00000047599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GHRH-R; GHRHREC
Orthologs
human mouse all
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Genomic context

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See GHRHR in Genome Data Viewer
Location:
chromosome: 4
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (65395704..65411699, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene neuronal differentiation 6 Neighboring gene ADCYAP receptor type I Neighboring gene uncharacterized LOC112446389 Neighboring gene oxysterol-binding protein-related protein 9-like Neighboring gene aquaporin 1 Neighboring gene MINDY lysine 48 deubiquitinase 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. A 5'UTR SNP of GHRHR locus is associated with body weight and average daily gain in Chinese cattle. Zhang CF, et al. Mol Biol Rep, 2012 Dec. PMID 23053950
  2. Characterization and expression of the bovine growth hormone-releasing hormone (GHRH) receptor. Connor EE, et al. Domest Anim Endocrinol, 2002 Jun. PMID 12044609
  3. Molecular cloning of ovine and bovine growth hormone-releasing hormone receptors: the ovine receptor is C-terminally truncated. Horikawa R, et al. Endocrinology, 2001 Jun. PMID 11356717
  4. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth hormone-releasing hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth hormone-releasing hormone receptor
Names
bovine growth hormone-releasing hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181020.3 → NP_851363.1  growth hormone-releasing hormone receptor precursor

    See identical proteins and their annotated locations for NP_851363.1

    Status: VALIDATED

    Source sequence(s)
    AB022597
    UniProtKB/TrEMBL
    F1N114, Q9N1F8, Q9TUJ0
    Related
    ENSBTAP00000026967.4, ENSBTAT00000026967.5
    Conserved Domains (2) summary
    pfam00002
    Location:126 → 374
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52 → 112
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    65395704..65411699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059885402.1 → XP_059741385.1  growth hormone-releasing hormone receptor isoform X2

    UniProtKB/TrEMBL
    Q9N1F8

  2. XM_010804293.4 → XP_010802595.1  growth hormone-releasing hormone receptor isoform X3

    See identical proteins and their annotated locations for XP_010802595.1

    UniProtKB/TrEMBL
    A0A3S5ZP58, F1MF96, Q9N1F8, Q9TUJ1
    Related
    ENSBTAP00000043543.5, ENSBTAT00000046224.5
    Conserved Domains (2) summary
    pfam00002
    Location:126 → 372
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52 → 112
    HRM; Hormone receptor domain

  3. XM_010804289.4 → XP_010802591.1  growth hormone-releasing hormone receptor isoform X1

    UniProtKB/TrEMBL
    Q9N1F8
    Conserved Domains (2) summary
    pfam00002
    Location:126 → 372
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52 → 112
    HRM; Hormone receptor domain

  4. XM_059885405.1 → XP_059741388.1  growth hormone-releasing hormone receptor isoform X5

    UniProtKB/TrEMBL
    Q9N1F8

  5. XM_059885404.1 → XP_059741387.1  growth hormone-releasing hormone receptor isoform X4

    UniProtKB/TrEMBL
    Q9N1F8
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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