CLIC5 chloride intracellular channel 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CLIC5provided by VGNC
Official Full Name: chloride intracellular channel 5provided by VGNC
Primary source: VGNC:VGNC:107286
See related: Ensembl:ENSBTAG00000010244
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (19180481..19350762, complement)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLIC5A colocalizes with ezrin and podocalyxin in podocytes and is required for the development/maintenance of the proper glomerular endothelial cell and podocyte architecture.
Title: CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BM1258 (e-PCR), detects polymorphism
- UniSTS:56663

AF042207 (e-PCR)
- UniSTS:51145

General protein information

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Preferred Names: chloride intracellular channel protein 5

Names: chloride channel protein p64; chlorine channel protein p64; glutaredoxin-like oxidoreductase CLIC5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174276.3 → NP_776701.1 chloride intracellular channel protein 5

See identical proteins and their annotated locations for NP_776701.1

Status: PROVISIONAL

Source sequence(s)

L16547

UniProtKB/Swiss-Prot

P35526

UniProtKB/TrEMBL

F1MIH4

Related

ENSBTAP00000013537.4, ENSBTAT00000013537.6

Conserved Domains (3) summary

TIGR00862
Location:199 → 435

O-ClC; intracellular chloride channel protein

cd10297
Location:293 → 434

GST_C_CLIC5; C-terminal, alpha helical domain of Chloride Intracellular Channel 5

cd03061
Location:199 → 286

GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...