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UCP1 uncoupling protein 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281561, updated on 1-Jan-2025

Summary

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Official Symbol
UCP1provided by VGNC
Official Full Name
uncoupling protein 1provided by VGNC
Primary source
VGNC:VGNC:36640
See related
BGD:BT14310; Ensembl:ENSBTAG00000004647
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See UCP1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (17164396..17171257)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 150 Neighboring gene transfer RNA arginine (anticodon CCU) Neighboring gene TBC1 domain family member 9 Neighboring gene uncharacterized LOC132342583 Neighboring gene ELMO domain containing 2 Neighboring gene MGAT4 family member D

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Possibility of uncoupling protein 1 expression in bovine fast-twitch muscle fibers. Diao Z, et al. J Vet Med Sci, 2023 Jun 1. PMID 37062711, Free PMC Article
  2. Regulatory expression of uncoupling protein 1 and its related genes by endogenous activity of the transforming growth factor-β family in bovine myogenic cells. Abd Eldaim MA, et al. Cell Biochem Funct, 2021 Jan. PMID 33006416
  3. Expression of uncoupling protein 1 in bovine muscle cells. Abd Eldaim MA, et al. J Anim Sci, 2016 Dec. PMID 28046166
  4. Haplotypic variation in the UCP1 gene is associated with milk traits in dairy cows. Zhou H, et al. J Dairy Res, 2017 Feb. PMID 27691991
  5. Mapping of the UCP1 locus to bovine chromosome 17. Sonstegard TS, et al. Anim Genet, 1999 Dec. PMID 10612249

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Possibility of uncoupling protein 1 expression in bovine fast-twitch muscle fibers.
    Title: Possibility of uncoupling protein 1 expression in bovine fast-twitch muscle fibers.
  2. Regulatory expression of uncoupling protein 1 and its related genes by endogenous activity of the transforming growth factor-beta family in bovine myogenic cells.
    Title: Regulatory expression of uncoupling protein 1 and its related genes by endogenous activity of the transforming growth factor-β family in bovine myogenic cells.
  3. The results of the present study provide an insight into the unexpected expression of Ucp1 in bovine skeletal muscle, which suggests the necessity for further studies on Ucp1-mediated energy expenditure in bovine skeletal muscle.
    Title: Expression of uncoupling protein 1 in bovine muscle cells.
  4. study suggests that uncoupling protein 1 affects milk yield, milk fat percentage and milk protein percentage
    Title: Haplotypic variation in the UCP1 gene is associated with milk traits in dairy cows.
  5. These results suggest that CIDE-A and UCP1 are regulated by insulin and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.
    Title: Saturated fatty acids stimulate and insulin suppresses CIDE-A expression in bovine mammary epithelial cells.
  6. UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
    Title: Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oxidative phosphorylation uncoupler activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive thermogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial brown fat uncoupling protein 1
Names
UCP 1
mitochondrial, proton carrier
solute carrier family 25 member 7
thermogenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166528.1 → NP_001160000.1  mitochondrial brown fat uncoupling protein 1

    See identical proteins and their annotated locations for NP_001160000.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000017
    UniProtKB/Swiss-Prot
    F1MTU3, P10861
    Conserved Domains (2) summary
    PTZ00169
    Location:21 → 299
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:111 → 208
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    17164396..17171257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059875873.1 → XP_059731856.1  mitochondrial brown fat uncoupling protein 1 isoform X2

  2. XM_059875872.1 → XP_059731855.1  mitochondrial brown fat uncoupling protein 1 isoform X1

    UniProtKB/TrEMBL
    A0AAF6YMU9
    Related
    ENSBTAP00000006097.6, ENSBTAT00000006097.7

  3. XM_059875874.1 → XP_059731857.1  mitochondrial brown fat uncoupling protein 1 isoform X3

    UniProtKB/TrEMBL
    A0AAA9TV77
    Related
    ENSBTAP00000100485.1, ENSBTAT00000111215.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10861.3 GenPept UniProtKB/Swiss-Prot:P10861

Gene LinkOut

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