TP53 tumor protein p53 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TP53provided by VGNC
Official Full Name: tumor protein p53provided by VGNC
Primary source: VGNC:VGNC:36231
See related: BGD:BT10936; Ensembl:ENSBTAG00000001069
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (27376071..27388416, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the HSP90 inhibitor 17-DMAG, counteracted the LPS - induced effects both in vivo and in vitro. Specifically, this hsp90 inhibitor reduced phosphorylated P53 levels and lessened the activation of myosin light chain 2 (phosphorylation)
Title: Hsp90 inhibitors suppress P53 phosphorylation in LPS - induced endothelial inflammation.
our study proved that the expression of Hsp27/P53 differed across the testis developmental stages and the expression of P53 was higher in the testis of cattle-yak, which suggested that the infertility of cattle-yak may be caused by the upregulation of P53.
Title: Regulation by Hsp27/P53 in testis development and sperm apoptosis of male cattle (cattle-yak and yak).
The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A are reported.
Title: P53-Mediated Repression of the Reprogramming in Cloned Bovine Embryos Through Direct Interaction with HDAC1 and Indirect Interaction with DNMT3A.
Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes
Title: Dispersal of an ancient retroposon in the TP53 promoter of Bovidae: phylogeny, novel mechanisms, and potential implications for cow milk persistency.
Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.
Title: p66shc, but not p53, is involved in early arrest of in vitro-produced bovine embryos.
PI3K/Akt and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Title: Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cellular tumor antigen p53

Names: p53 tumor suppressor phosphoprotein; tumor protein 53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174201.2 → NP_776626.1 cellular tumor antigen p53

See identical proteins and their annotated locations for NP_776626.1

Status: PROVISIONAL

Source sequence(s)

BC102440

UniProtKB/Swiss-Prot

P67939, Q3ZCF1

UniProtKB/TrEMBL

F1SY23, Q0Z9Z4

Related

ENSBTAP00000001420.3, ENSBTAT00000001420.4

Conserved Domains (3) summary

pfam00870
Location:87 → 282

P53; P53 DNA-binding domain

pfam07710
Location:312 → 351

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:5 → 28

P53_TAD; P53 transactivation motif