SELL selectin L [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: SELL
Gene description: selectin L
See related: Ensembl:ENSBTAG00000011515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (37340129..37365752, complement)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP.
Title: Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows.
gammadelta T cells, the main recirculating subset in both afferent and efferent lymph, have high levels of CD62L cell surface expression.
Title: γδ T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent.
demonstrate the existence of central memory T cells (Tcm) in cattle and suggest that CD62L may serve as a marker to monitor Tcm in infections and vaccine development studies in ruminant.
Title: CD62L defines a subset of pathogen-specific bovine CD4 with central memory cell characteristics.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
Title: L-selectin and beta2-integrin expression on circulating bovine polymorphonuclear leukocytes during endotoxin mastitis.
results indicate that glucocorticoid-induced suppression of L-selectin is likely mediated by direct effects of glucocorticoid receptor activation on intracellular reservoirs of L-selectin mRNA and protein, predominantly in blood neutrophils.
Title: Mechanisms of glucocorticoid-induced down-regulation of neutrophil L-selectin in cattle: evidence for effects at the gene-expression level and primarily on blood neutrophils.
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle
Title: Expression of L-Selectin (CD62L), CD44, and CD25 on activated bovine T cells.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in leukocyte migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: L-selectin

Names: CD62 antigen-like family member L; LAM-1; LECAM1; leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 1; lymph node homing receptor; lymphocyte adhesion molecule 1; selectin L (lymphocyte adhesion molecule 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.