U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRP1 prolactin-related protein 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281429, updated on 30-Jan-2025

Summary

Go to the top of the page Help
Gene symbol
PRP1
Gene description
prolactin-related protein 1
See related
BGD:BT27898; EnsemblRapid:ENSBTAG00070005354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GHE3
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PRP1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (34765570..34777652, complement)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443892 Neighboring gene prolactin-related protein VI Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene chorionic somatomammotropin hormone 2 Neighboring gene U6 spliceosomal RNA Neighboring gene chorionic somatomammotropin hormone 2-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cleaved bovine prolactin-related protein-I stimulates vascular endothelial cell proliferation. Ushizawa K, et al. Mol Cell Endocrinol, 2010 Jul 29. PMID 20298748
  2. Bovine prolactin-related protein-I is anchored to the extracellular matrix through interactions with type IV collagen. Takahashi T, et al. J Endocrinol, 2008 Feb. PMID 18252946
  3. In bovine binucleate trophoblast giant cells, pregnancy-associated glycoproteins and placental prolactin-related protein-I are conjugated to asparagine-linked N-acetylgalactosaminyl glycans. Klisch K, et al. Histochem Cell Biol, 2003 Mar. PMID 12649735
  4. Molecular cloning of a prolactin-related mRNA expressed in bovine placenta. Schuler LA, et al. Proc Natl Acad Sci U S A, 1987 Aug. PMID 3475696, Free PMC Article
  5. Characterization of the gene corresponding to bovine placental prolactin-related cDNA I: evolutionary implications. Ebbitt DM, et al. DNA, 1989 Apr. PMID 2721368

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that cleaved PRP1 proliferates endothelial cells in vitro, and suggest that endothelial cell proliferation activity of cleaved PRP1 may be shared in specific bovine placentomal angiogenesis.
    Title: Cleaved bovine prolactin-related protein-I stimulates vascular endothelial cell proliferation.
  2. Identified novel prolactin-related proteins (PRPs) in caprine placenta, and indicated that PRP genes in caprine placenta have coordination functions for gestation, as they do in bovine.
    Title: Gene expression profiles of novel caprine placental prolactin-related proteins similar to bovine placental prolactin-related proteins.
  3. Interaction of bPRP-I with type IV collagen suggests that bPRP-I accumulates in extracellular matrix where it likely acts on cells traversing the bovine placentome.
    Title: Bovine prolactin-related protein-I is anchored to the extracellular matrix through interactions with type IV collagen.
  4. placental prolactin-related protein-I is identified as a major target of bovine binucleate trophoblast giant cell lectin binding
    Title: In bovine binucleate trophoblast giant cells, pregnancy-associated glycoproteins and placental prolactin-related protein-I are conjugated to asparagine-linked N-acetylgalactosaminyl glycans.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables prolactin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mammary gland development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of lactation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
placental prolactin-related protein 1
Names
PRC-I
bPRCI
growth hormone E3
prolactin-related protein 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174159.3 → NP_776584.2  placental prolactin-related protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    NKLS02000023
    UniProtKB/Swiss-Prot
    A6QPR5, P05402
    UniProtKB/TrEMBL
    Q1ECS8
    Related
    ENSBTAP00070006910.1, ENSBTAT00070012242.1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34765570..34777652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05402.2 GenPept UniProtKB/Swiss-Prot:P05402

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials