PRLR prolactin receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PRLRprovided by VGNC
Official Full Name: prolactin receptorprovided by VGNC
Primary source: VGNC:VGNC:33346
See related: BGD:BT12471; Ensembl:ENSBTAG00000025035
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: SPRLR
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	20	NC_037347.1 (38915987..39108971)

Chromosome 20 - NC_037347.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inheritance of the SLICK1 allele of PRLR in cattle.
Title: Inheritance of the SLICK1 allele of PRLR in cattle.
rs135164815 (P = 0.033) and rs136247583 (P = 0.049) were associated with fertility in hot-humid climate
Title: Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate.
The presence and localization of prolactin receptor are consistent with expression data reported for other species, and the presence of PIP and prolactin in seminal fluid is consistent with data generated in humans.
Title: Identification of bovine prolactin in seminal fluid, and expression and localization of the prolactin receptor and prolactin-inducible protein in the testis and epididymis of bulls exposed to ergot alkaloids.
This study revealed for the first time that the PRLR gene is a promising candidate gene that affects growth traits in cattle.
Title: Single nucleotide polymorphisms of the prolactin receptor (PRLR) gene and its association with growth traits in Chinese cattle.
determination of the effects of exposure to different lengths of daylight during the dry period on circulating PRL and PRL receptor mRNA expression in lymphocytes and mammary tissue during the transition to lactation
Title: Effects of photoperiod during the dry period on prolactin, prolactin receptor, and milk production of dairy cows.
Multiple internalization motifs differentially used by this protein's isoforms mediate similar endocytic pathways.
Title: Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways.

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General gene information

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Markers

PRLR (e-PCR)
- UniSTS:505783

Prlr (e-PCR), detects polymorphism
- UniSTS:505783

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info	PubMed
enables prolactin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prolactin receptor

Names: PRL-R; prolactin receptor long form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039726.2 → NP_001034815.1 prolactin receptor long isoform precursor

See identical proteins and their annotated locations for NP_001034815.1

Status: PROVISIONAL

Source sequence(s)

L02549

UniProtKB/Swiss-Prot

O18880, O46591, Q28172

UniProtKB/TrEMBL

Q2PBN9

Related

ENSBTAP00000014437.5, ENSBTAT00000014437.5

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 362

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 119

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_174155.3 → NP_776580.1 prolactin receptor short isoform precursor

See identical proteins and their annotated locations for NP_776580.1

Status: PROVISIONAL

Source sequence(s)

AF027403

UniProtKB/TrEMBL

Q2PBP0

Related

ENSBTAP00000063878.2, ENSBTAT00000082398.2

Conserved Domains (2) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:23 → 119

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

Range

38915987..39108971

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024981203.2 → XP_024836971.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

F1N4H8, Q2PBN9

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 395

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_024981208.2 → XP_024836976.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

Q2PBP0

Conserved Domains (2) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_024981202.2 → XP_024836970.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

F1N4H8, Q2PBN9

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 395

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_024981206.2 → XP_024836974.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

F1N4H8, Q2PBN9

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 395

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_024981210.2 → XP_024836978.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

Q2PBP0

Conserved Domains (2) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_005221577.5 → XP_005221634.1 prolactin receptor isoform X1

See identical proteins and their annotated locations for XP_005221634.1

UniProtKB/TrEMBL

F1N4H8, Q2PBN9

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 395

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_024981211.2 → XP_024836979.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

Q2PBP0

Conserved Domains (2) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_024981207.2 → XP_024836975.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

F1N4H8, Q2PBN9

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 395

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_005221576.5 → XP_005221633.1 prolactin receptor isoform X1

See identical proteins and their annotated locations for XP_005221633.1

UniProtKB/TrEMBL

F1N4H8, Q2PBN9

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 395

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_005221579.5 → XP_005221636.1 prolactin receptor isoform X2

See identical proteins and their annotated locations for XP_005221636.1

UniProtKB/TrEMBL

Q2PBP0

Conserved Domains (2) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_005221575.5 → XP_005221632.1 prolactin receptor isoform X1

See identical proteins and their annotated locations for XP_005221632.1

UniProtKB/TrEMBL

F1N4H8, Q2PBN9

Conserved Domains (3) summary

cd00063
Location:127 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:286 → 395

GHBP; Growth hormone receptor binding

cl21522
Location:23 → 120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...