U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PPT1 palmitoyl-protein thioesterase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281421, updated on 27-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
PPT1provided by VGNC
Official Full Name
palmitoyl-protein thioesterase 1provided by VGNC
Primary source
VGNC:VGNC:33277
See related
BGD:BT10053; Ensembl:ENSBTAG00000013367
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CLN1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PPT1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (106020412..106036783)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene RLF zinc finger Neighboring gene uncharacterized LOC132344934 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene transfer RNA arginine (anticodon CCU) Neighboring gene cyclase associated actin cytoskeleton regulatory protein 1 Neighboring gene uncharacterized LOC132344935

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Bellizzi JJ 3rd, et al. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781062, Free PMC Article
  2. Lysosomal targeting of palmitoyl-protein thioesterase. Verkruyse LA, et al. J Biol Chem, 1996 Jun 28. PMID 8663305
  3. Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. Camp LA, et al. J Biol Chem, 1993 Oct 25. PMID 7901201
  4. Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis. Hellsten E, et al. EMBO J, 1996 Oct 1. PMID 8895569, Free PMC Article
  5. Molecular cloning and expression of palmitoyl-protein thioesterase. Camp LA, et al. J Biol Chem, 1994 Sep 16. PMID 7916016

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein depalmitoylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
palmitoyl-protein thioesterase 1
Names
PPT-1
palmitoyl protein thioesterase
palmitoyl-protein hydrolase 1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
NP_776579.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174154.2 → NP_776579.1  palmitoyl-protein thioesterase 1 precursor

    See identical proteins and their annotated locations for NP_776579.1

    Status: PROVISIONAL

    Source sequence(s)
    L34261
    UniProtKB/Swiss-Prot
    A7YWB2, P45478
    UniProtKB/TrEMBL
    A0AAA9SUX8
    Related
    ENSBTAP00000017780.5, ENSBTAT00000017780.6
    Conserved Domains (1) summary
    cl21494
    Location:28 → 306
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    106020412..106036783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45478.1 GenPept UniProtKB/Swiss-Prot:P45478

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials