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NEU3 neuraminidase 3 [ Bos taurus (domestic cattle) ]

Gene ID: 281349, updated on 30-Jan-2025

Summary

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Official Symbol
NEU3provided by VGNC
Official Full Name
neuraminidase 3provided by VGNC
Primary source
VGNC:VGNC:54889
See related
BGD:BT10628; EnsemblRapid:ENSBTAG00070031738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NEU3 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (54247469..54270762)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene signal peptidase complex subunit 2 Neighboring gene olfactory receptor family 2 subfamily AT member 2C Neighboring gene olfactory receptor family 2 subfamily AT member 2B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a plasma membrane-associated sialidase specific for gangliosides. Miyagi T, et al. J Biol Chem, 1999 Feb 19. PMID 9988745
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables exo-alpha-sialidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ganglioside catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in oligosaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sialidase-3
Names
N-acetyl-alpha-neuraminidase 3
ganglioside sialidase
membrane sialidase
sialidase 3 (membrane sialidase)
NP_776547.2
XP_010810989.1
XP_024830753.1
XP_024830754.1
XP_059730535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174122.3 → NP_776547.2  sialidase-3

    Status: VALIDATED

    Source sequence(s)
    AB008184
    UniProtKB/Swiss-Prot
    O97859
    Related
    ENSBTAP00070043850.1, ENSBTAT00070071822.1
    Conserved Domains (2) summary
    cd15482
    Location:21 → 414
    Sialidase_non-viral; Non-viral sialidases
    pfam13088
    Location:47 → 395
    BNR_2; BNR repeat-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    54247469..54270762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059874552.1 → XP_059730535.1  sialidase-3 isoform X1

    UniProtKB/Swiss-Prot
    O97859
    UniProtKB/TrEMBL
    A0AAA9TU08

  2. XM_024974985.2 → XP_024830753.1  sialidase-3 isoform X1

    UniProtKB/Swiss-Prot
    O97859
    UniProtKB/TrEMBL
    A0AAA9TU08
    Related
    ENSBTAP00070043815.1, ENSBTAT00070071771.1
    Conserved Domains (1) summary
    cd15482
    Location:55 → 448
    Sialidase_non-viral; Non-viral sialidases

  3. XM_024974986.2 → XP_024830754.1  sialidase-3 isoform X2

    UniProtKB/Swiss-Prot
    O97859
    Conserved Domains (1) summary
    cd15482
    Location:25 → 418
    Sialidase_non-viral; Non-viral sialidases

  4. XM_010812687.4 → XP_010810989.1  sialidase-3 isoform X2

    See identical proteins and their annotated locations for XP_010810989.1

    UniProtKB/Swiss-Prot
    O97859
    Related
    ENSBTAP00070043797.1, ENSBTAT00070071744.1
    Conserved Domains (1) summary
    cd15482
    Location:25 → 418
    Sialidase_non-viral; Non-viral sialidases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97859.1 GenPept UniProtKB/Swiss-Prot:O97859

Gene LinkOut

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Molecular Biology Databases
Research Materials