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NCF2 neutrophil cytosolic factor 2 [ Bos taurus (domestic cattle) ]

Gene ID: 281346, updated on 27-Dec-2024

Summary

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Official Symbol
NCF2provided by VGNC
Official Full Name
neutrophil cytosolic factor 2provided by VGNC
Primary source
VGNC:VGNC:31912
See related
BGD:BT27828; Ensembl:ENSBTAG00000008004
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NCF2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (64605720..64638796, complement)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene SMG7 nonsense mediated mRNA decay factor Neighboring gene actin related protein 2/3 complex subunit 5 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene ral guanine nucleotide dissociation stimulator like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Cloning and expression of bovine p47-phox and p67-phox: comparison with the human and murine homologs. Bunger PL, et al. J Leukoc Biol, 2000 Jan. PMID 10647999
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC179493

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in respiratory burst IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neutrophil cytosol factor 2
Names
67 kDa neutrophil oxidase factor
NCF-2
neutrophil NADPH oxidase factor 2
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
p67-phox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174120.2 → NP_776545.1  neutrophil cytosol factor 2

    See identical proteins and their annotated locations for NP_776545.1

    Status: PROVISIONAL

    Source sequence(s)
    AF079303
    UniProtKB/Swiss-Prot
    O77775
    UniProtKB/TrEMBL
    A0AAA9T2A3
    Related
    ENSBTAP00000058209.1, ENSBTAT00000076657.2
    Conserved Domains (7) summary
    cd06406
    Location:351 → 430
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244 → 297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:462 → 513
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    sd00006
    Location:37 → 65
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:71 → 98
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:71 → 150
    TPR_11; TPR repeat
    pfam13424
    Location:38 → 102
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    64605720..64638796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005217265.5 → XP_005217322.1  neutrophil cytosol factor 2 isoform X3

    UniProtKB/TrEMBL
    A0AAA9T2A3, F1N733
    Conserved Domains (7) summary
    cd06406
    Location:350 → 429
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244 → 297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:461 → 512
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    sd00006
    Location:37 → 65
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:71 → 98
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:71 → 150
    TPR_11; TPR repeat
    pfam13424
    Location:38 → 102
    TPR_12; Tetratricopeptide repeat

  2. XM_059875221.1 → XP_059731204.1  neutrophil cytosol factor 2 isoform X2

    UniProtKB/TrEMBL
    A0AAA9SWD7

  3. XM_059875220.1 → XP_059731203.1  neutrophil cytosol factor 2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9SWD7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77775.1 GenPept UniProtKB/Swiss-Prot:O77775

Gene LinkOut

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