U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MSR1 macrophage scavenger receptor 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281311, updated on 1-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
MSR1provided by VGNC
Official Full Name
macrophage scavenger receptor 1provided by VGNC
Primary source
VGNC:VGNC:31704
See related
BGD:BT16011; Ensembl:ENSBTAG00000002885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MSR1 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (20909945..20990322)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene tumor suppressor candidate 3 Neighboring gene putative methyltransferase NSUN5C

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Rohrer L, et al. Nature, 1990 Feb 8. PMID 2300208
  2. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Kodama T, et al. Nature, 1990 Feb 8. PMID 2300204
  3. HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Nakamura T, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785981
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic cleft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
macrophage scavenger receptor types I and II
Names
macrophage acetylated LDL receptor I and II

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113240.1 → NP_001106711.1  macrophage scavenger receptor types I and II isoform 1

    See identical proteins and their annotated locations for NP_001106711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and protein isoform (1).
    Source sequence(s)
    AJ677598, AM037916, DY085614, X51689
    UniProtKB/Swiss-Prot
    A5PJV2, P21758
    UniProtKB/TrEMBL
    A0AAF6YK38
    Related
    ENSBTAP00000003751.4, ENSBTAT00000003751.5
    Conserved Domains (4) summary
    pfam01391
    Location:279 → 333
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:352 → 452
    SR; Scavenger receptor Cys-rich
    pfam03523
    Location:120 → 168
    Macscav_rec; Macrophage scavenger receptor
    cl25732
    Location:111 → 253
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_174113.2 → NP_776538.1  macrophage scavenger receptor types I and II isoform 2

    See identical proteins and their annotated locations for NP_776538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct terminal exon resulting in a shorter protein isoform (2).
    Source sequence(s)
    AM018111, DY085614, X51689, X54183
    UniProtKB/Swiss-Prot
    P21758
    Related
    ENSBTAP00000003755.5, ENSBTAT00000003755.6
    Conserved Domains (3) summary
    pfam01391
    Location:279 → 333
    Collagen; Collagen triple helix repeat (20 copies)
    pfam03523
    Location:120 → 168
    Macscav_rec; Macrophage scavenger receptor
    cl25732
    Location:111 → 253
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    20909945..20990322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21758.1 GenPept UniProtKB/Swiss-Prot:P21758

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials