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FSHR follicle stimulating hormone receptor [ Bos taurus (domestic cattle) ]

Gene ID: 281172, updated on 1-Jan-2025

Summary

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Official Symbol
FSHRprovided by VGNC
Official Full Name
follicle stimulating hormone receptorprovided by VGNC
Primary source
VGNC:VGNC:29132
See related
Ensembl:ENSBTAG00000032424
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See FSHR in Genome Data Viewer
Location:
chromosome: 11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (31255649..31450534, complement)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene general transcription factor IIA subunit 1 like Neighboring gene uncharacterized LOC132346571 Neighboring gene luteinizing hormone/choriogonadotropin receptor Neighboring gene uncharacterized LOC132346572 Neighboring gene uncharacterized LOC132346513

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Kisspeptin stimulates oestradiol biosynthesis by upregulating steroidogenic transcripts and proliferation markers in the bubaline granulosa cells in vitro. Sharma R, et al. Reprod Domest Anim, 2024 Jan. PMID 38268209
  2. FSHR genotype affects estrogen levels but not pregnancy rates in Luxi cattle subjected to embryo transfer. Yang WC, et al. Genet Mol Res, 2014 Mar 12. PMID 24668630
  3. Identification of single nucleotide polymorphisms in the bovine follicle-stimulating hormone receptor and effects of genotypes on superovulatory response traits. Cory AT, et al. Anim Genet, 2013 Apr. PMID 22670622
  4. Structure of the bovine follicle-stimulating hormone receptor complementary DNA and expression in bovine tissues. Houde A, et al. Mol Reprod Dev, 1994 Oct. PMID 7826612
  5. mRNA expression pattern of gonadotropin receptors in bovine follicular cysts. Marelli BE, et al. Reprod Biol, 2014 Dec. PMID 25454493

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
    Title: INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS (EAST ANATOLLAN RED, SOUTH ANATOLIAN RED, TURKISH GREY, ANATOLIAN BLACK AND ZAVOT).
  2. The expression of FSHR mRNA in granulosa cells was highest in small antral follicles, then decreased significantly as follicles increased in size, and was lowest in cysts.
    Title: mRNA expression pattern of gonadotropin receptors in bovine follicular cysts.
  3. transfer. We conclude that variation at these loci of the FSHR gene has no significant effect on pregnancy rates in Luxi cattle.
    Title: FSHR genotype affects estrogen levels but not pregnancy rates in Luxi cattle subjected to embryo transfer.
  4. Specific alleles of the bovine FSHR gene are associated with variations in embryo yield and in the number of unfertilised oocytes.
    Title: Identification of single nucleotide polymorphisms in the bovine follicle-stimulating hormone receptor and effects of genotypes on superovulatory response traits.
  5. This study evaluated the relationships among aromatase, IGF-1, IGF2R, and follicle stimulating hormone (FSH) receptor levels expressed in ovarian follicles of cattle selected for twin pregnancies.
    Title: Increased abundance of aromatase and follicle stimulating hormone receptor mRNA and decreased insulin-like growth factor-2 receptor mRNA in small ovarian follicles of cattle selected for twin births.
  6. Heterozygous heifers showed a higher pregnancy rate (67 and 66% for LHR and FSHR genes, respectively), but no significant effects were observed for the genes studied (
    Title: Effects of polymorphisms of LHR and FSHR genes on sexual precocity in a Bos taurus x Bos indicus beef composite population.
  7. FSHR is specifically regulated through androgen receptor in granulosa cells
    Title: Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells.
  8. Dominant follicles experience a reduction in FSH dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR) as they grow during the low FSH milieu of follicular waves.
    Title: Molecular evidence that growth of dominant follicles involves a reduction in follicle-stimulating hormone dependence and an increase in luteinizing hormone dependence in cattle.
  9. granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production
    Title: Temporal relationships between FSH receptor, type 1 insulin-like growth factor receptor, and aromatase expression during FSH-induced differentiation of bovine granulosa cells maintained in serum-free culture.
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Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables follicle-stimulating hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in follicle-stimulating hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
follicle-stimulating hormone receptor
Names
FSH-R
follitropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174061.1 → NP_776486.1  follicle-stimulating hormone receptor precursor

    See identical proteins and their annotated locations for NP_776486.1

    Status: PROVISIONAL

    Source sequence(s)
    L22319
    UniProtKB/Swiss-Prot
    P35376
    UniProtKB/TrEMBL
    F1MT42
    Related
    ENSBTAP00000048971.2, ENSBTAT00000056513.3
    Conserved Domains (6) summary
    smart00013
    Location:17 → 50
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:51 → 71
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:379 → 626
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam12369
    Location:282 → 349
    GnHR_trans; Gonadotropin hormone receptor transmembrane region
    pfam13306
    Location:61 → 216
    LRR_5; Leucine rich repeats (6 copies)
    pfam13855
    Location:193 → 245
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    31255649..31450534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059890999.1 → XP_059746982.1  follicle-stimulating hormone receptor isoform X3

    UniProtKB/TrEMBL
    F1MT42

  2. XM_059890998.1 → XP_059746981.1  follicle-stimulating hormone receptor isoform X2

    UniProtKB/TrEMBL
    F1MT42

  3. XM_024998262.2 → XP_024854030.1  follicle-stimulating hormone receptor isoform X5

    UniProtKB/TrEMBL
    F1MT42
    Conserved Domains (6) summary
    smart00013
    Location:17 → 50
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:99 → 122
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:72 → 93
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12369
    Location:232 → 299
    GnHR_trans; Gonadotropin hormone receptor transmembrane region
    pfam13855
    Location:143 → 195
    LRR_8; Leucine rich repeat
    cd15360
    Location:313 → 587
    7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_024998260.2 → XP_024854028.1  follicle-stimulating hormone receptor isoform X1

    UniProtKB/TrEMBL
    F1MT42
    Conserved Domains (6) summary
    smart00013
    Location:17 → 50
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:51 → 71
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12369
    Location:281 → 348
    GnHR_trans; Gonadotropin hormone receptor transmembrane region
    pfam13855
    Location:72 → 131
    LRR_8; Leucine rich repeat
    cd15360
    Location:362 → 636
    7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl26222
    Location:61 → 215
    LRR_5; Leucine rich repeats (6 copies)

  5. XM_024998261.2 → XP_024854029.1  follicle-stimulating hormone receptor isoform X4

    UniProtKB/TrEMBL
    A0AAA9SWP4
    Conserved Domains (7) summary
    smart00013
    Location:17 → 50
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:50 → 71
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:170 → 193
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12369
    Location:232 → 299
    GnHR_trans; Gonadotropin hormone receptor transmembrane region
    pfam13855
    Location:143 → 195
    LRR_8; Leucine rich repeat
    cd15360
    Location:313 → 587
    7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl26222
    Location:58 → 166
    LRR_5; Leucine rich repeats (6 copies)

  6. XM_024998263.2 → XP_024854031.1  follicle-stimulating hormone receptor isoform X6

    UniProtKB/TrEMBL
    F1MT42
    Conserved Domains (5) summary
    smart00013
    Location:17 → 50
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:72 → 96
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12369
    Location:224 → 287
    GnHR_trans; Gonadotropin hormone receptor transmembrane region
    cd15360
    Location:301 → 575
    7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl26222
    Location:61 → 216
    LRR_5; Leucine rich repeats (6 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35376.1 GenPept UniProtKB/Swiss-Prot:P35376

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