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EXT2 exostosin glycosyltransferase 2 [ Bos taurus (domestic cattle) ]

Gene ID: 281151, updated on 27-Dec-2024

Summary

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Official Symbol
EXT2provided by VGNC
Official Full Name
exostosin glycosyltransferase 2provided by VGNC
Primary source
VGNC:VGNC:28666
See related
BGD:BT29415; Ensembl:ENSBTAG00000019644
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See EXT2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (74203811..74352953)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Neighboring gene ALX homeobox 4 Neighboring gene small nucleolar RNA SNORA61 Neighboring gene CD82 molecule

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis. Senay C, et al. EMBO Rep, 2000 Sep. PMID 11256613, Free PMC Article
  2. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. Lind T, et al. J Biol Chem, 1998 Oct 9. PMID 9756849
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
exostosin-2
Names
HS-POL
HS-polymerase
exostoses (multiple) 2
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
glucuronyl/N-acetylglucosaminyl transferase
multiple exostoses protein 2 homolog
NP_803462.2
XP_005216463.2
XP_005216464.1
XP_010811099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177496.4 → NP_803462.2  exostosin-2

    See identical proteins and their annotated locations for NP_803462.2

    Status: PROVISIONAL

    Source sequence(s)
    BC126570
    UniProtKB/Swiss-Prot
    O77783
    UniProtKB/TrEMBL
    A0JN91, F1N5Y6
    Related
    ENSBTAP00000026177.6, ENSBTAT00000026177.6
    Conserved Domains (2) summary
    pfam03016
    Location:100 → 380
    Exostosin; Exostosin family
    pfam09258
    Location:456 → 697
    Glyco_transf_64; Glycosyl transferase family 64 domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    74203811..74352953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005216407.5 → XP_005216464.1  exostosin-2 isoform X3

    See identical proteins and their annotated locations for XP_005216464.1

    UniProtKB/Swiss-Prot
    O77783
    UniProtKB/TrEMBL
    A0JN91, F1N5Y6
    Conserved Domains (2) summary
    pfam03016
    Location:100 → 380
    Exostosin; Exostosin family
    pfam09258
    Location:456 → 697
    Glyco_transf_64; Glycosyl transferase family 64 domain

  2. XM_010812797.4 → XP_010811099.1  exostosin-2 isoform X2

    UniProtKB/Swiss-Prot
    O77783
    Related
    ENSBTAP00000070225.1, ENSBTAT00000077991.2
    Conserved Domains (2) summary
    pfam03016
    Location:100 → 380
    Exostosin; Exostosin family
    pfam09258
    Location:412 → 646
    Glyco_transf_64; Glycosyl transferase family 64 domain

  3. XM_005216406.5 → XP_005216463.2  exostosin-2 isoform X1

    UniProtKB/Swiss-Prot
    O77783
    Related
    ENSBTAP00000099310.1, ENSBTAT00000132401.1
    Conserved Domains (2) summary
    pfam03016
    Location:100 → 380
    Exostosin; Exostosin family
    pfam09258
    Location:456 → 674
    Glyco_transf_64; Glycosyl transferase family 64 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77783.1 GenPept UniProtKB/Swiss-Prot:O77783

Gene LinkOut

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Molecular Biology Databases
Research Materials