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DPP4 dipeptidyl peptidase 4 [ Bos taurus (domestic cattle) ]

Gene ID: 281122, updated on 1-Jan-2025

Summary

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Official Symbol
DPP4provided by VGNC
Official Full Name
dipeptidyl peptidase 4provided by VGNC
Primary source
VGNC:VGNC:106715
See related
Ensembl:ENSBTAG00000048246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ACT3; CD26; WC10; DPPIV; ADCP-I
Orthologs
human mouse all
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Genomic context

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See DPP4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (34382851..34467589)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene fibroblast activation protein alpha Neighboring gene uncharacterized LOC112442563 Neighboring gene glucagon Neighboring gene solute carrier family 4 member 10 Neighboring gene ribulose-phosphate 3-epimerase-like Neighboring gene ATP synthase subunit f, mitochondrial-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Proline-rich cytokine from neurosecretory granules: a new natural substrate for dipeptidyl peptidase IV. Antonyan AA, et al. Neurochem Res, 2011 Jan. PMID 20838887
  2. Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes. Dubois V, et al. Front Biosci, 2008 May 1. PMID 18508455
  3. Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen. Lee SU, et al. Immunogenetics, 2002 Jun. PMID 12073152
  4. Identity of activation molecule 3 on superantigen-stimulated bovine cells is CD26. Lee SU, et al. Infect Immun, 2001 Nov. PMID 11598101, Free PMC Article
  5. CD26 is expressed on a restricted subpopulation of dendritic cells in vivo. Gliddon DR, et al. Eur J Immunol, 2002 May. PMID 11981836

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe a proline-rich cytokine from neurosecretory granules that represents a new natural substrate for Dipeptidyl Peptidase IV (DPPIV).
    Title: Proline-rich cytokine from neurosecretory granules: a new natural substrate for dipeptidyl peptidase IV.
  2. Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV.
    Title: Complex of dipeptidyl peptidase II with adenosine deaminase.
  3. This and other dipeptidyl peptidases can be isolated from bovine testes.
    Title: Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dipeptidyl peptidase 4
Names
T-cell activation antigen CD26
activation molecule 3
adenosine deaminase complexing protein
dipeptidyl peptidase IV
dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
NP_776464.1
XP_059747274.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174039.3 → NP_776464.1  dipeptidyl peptidase 4

    See identical proteins and their annotated locations for NP_776464.1

    Status: PROVISIONAL

    Source sequence(s)
    AF461806
    UniProtKB/Swiss-Prot
    P81425, Q3ZCC2, Q8WMG8
    UniProtKB/TrEMBL
    A0AAF6ZJE9
    Related
    ENSBTAP00000049191.4, ENSBTAT00000056886.4
    Conserved Domains (3) summary
    COG1506
    Location:397 → 763
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:558 → 762
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:107 → 477
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34382851..34467589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059891291.1 → XP_059747274.1  dipeptidyl peptidase 4 isoform X1

    UniProtKB/TrEMBL
    F1MTV0
    Related
    ENSBTAP00000084221.1, ENSBTAT00000110680.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81425.3 GenPept UniProtKB/Swiss-Prot:P81425

Gene LinkOut

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