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BCAN brevican [ Bos taurus (domestic cattle) ]

Gene ID: 281019, updated on 1-Jan-2025

Summary

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Official Symbol
BCANprovided by VGNC
Official Full Name
brevicanprovided by VGNC
Primary source
VGNC:VGNC:26434
See related
BGD:BT16521; Ensembl:ENSBTAG00000015789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See BCAN in Genome Data Viewer
Location:
chromosome: 3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (14176879..14195174, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene nestin Neighboring gene uncharacterized LOC104971465 Neighboring gene hyaluronan and proteoglycan link protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family. Yamada H, et al. J Biol Chem, 1994 Apr 1. PMID 8144512
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in skeletal system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perineuronal net IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
brevican core protein
Names
chondroitin sulfate proteoglycan BEHAB/brevican

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244125.1 → NP_001231054.1  brevican core protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks several 3' exons but includes an alternate 3' exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC134425, DV908732, EE239820
    UniProtKB/TrEMBL
    A4IF65
    Conserved Domains (4) summary
    smart00410
    Location:44 → 154
    IG_like; Immunoglobulin like
    cd03517
    Location:157 → 251
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:258 → 353
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    cl11960
    Location:49 → 158
    Ig; Immunoglobulin domain

  2. NM_173996.3 → NP_776421.2  brevican core protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_776421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    DV834628, DV870007, DV886436, DV888895, EE239820, EE242234
    UniProtKB/Swiss-Prot
    Q28062
    UniProtKB/TrEMBL
    F1MQ31
    Related
    ENSBTAP00000020965.3, ENSBTAT00000020965.5
    Conserved Domains (7) summary
    cd00033
    Location:816 → 873
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00410
    Location:44 → 154
    IG_like; Immunoglobulin like
    cd03517
    Location:157 → 251
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:258 → 353
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    pfam00008
    Location:651 → 680
    EGF; EGF-like domain
    cl02432
    Location:689 → 812
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:49 → 158
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    14176879..14195174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005203606.4 → XP_005203663.1  brevican core protein isoform X1

    See identical proteins and their annotated locations for XP_005203663.1

    UniProtKB/Swiss-Prot
    Q28062
    UniProtKB/TrEMBL
    F1MQ31
    Conserved Domains (7) summary
    cd00033
    Location:816 → 873
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00410
    Location:44 → 154
    IG_like; Immunoglobulin like
    cd03517
    Location:157 → 251
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:258 → 353
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    pfam00008
    Location:651 → 680
    EGF; EGF-like domain
    cl02432
    Location:689 → 812
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:49 → 158
    Ig; Immunoglobulin domain

  2. XM_059881462.1 → XP_059737445.1  brevican core protein isoform X1

    UniProtKB/Swiss-Prot
    Q28062
    UniProtKB/TrEMBL
    F1MQ31

  3. XM_059881465.1 → XP_059737448.1  brevican core protein isoform X2

    UniProtKB/Swiss-Prot
    Q28062
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28062.1 GenPept UniProtKB/Swiss-Prot:Q28062

Gene LinkOut

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