HBB hemoglobin, beta [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: HBB
Gene description: hemoglobin, beta
See related: BGD:BT11614; EnsemblRapid:ENSBTAG00070030004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: GLNA1
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Genomic context

Location:: chromosome: 15

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (48362354..48363996)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
Title: Molten globule of hemoglobin proceeds into aggregates and advanced glycated end products.
The acid-induced denaturation of Hb follows a highly symmetric mechanism.
Title: Symmetric behavior of hemoglobin alpha- and beta- subunits during acid-induced denaturation observed by electrospray mass spectrometry.

Submit: New GeneRIF Correction

General gene information

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Markers

REN97351 (e-PCR)
- UniSTS:422149

PMC110379P1 (e-PCR)
- UniSTS:270188

GDB:178694 (e-PCR)
- UniSTS:155040

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:499134

PMC115301P1 (e-PCR)
- UniSTS:270300

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables haptoglobin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hemoglobin alpha binding	IEA Inferred from Electronic Annotation more info	PubMed
enables organic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	IEA Inferred from Electronic Annotation more info	PubMed
part_of haptoglobin-hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hemoglobin subunit beta

Names: beta globin; globin A1; hemoglobin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.