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BRB brain ribonuclease [ Bos taurus (domestic cattle) ]

Gene ID: 280720, updated on 1-Jan-2025

Summary

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Gene symbol
BRB
Gene description
brain ribonuclease
See related
BGD:BT10784; Ensembl:ENSBTAG00000004950
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
BRN
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Genomic context

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See BRB in Genome Data Viewer
Location:
chromosome: 10
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (26256262..26257893)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene ribonuclease pancreatic Neighboring gene ribonuclease, RNase A family, 1 (pancreatic) Neighboring gene epididymal secretory protein E3-beta Neighboring gene ribonuclease 4-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs. Dentis JL, et al. Domest Anim Endocrinol, 2016 Apr. PMID 26773365, Free PMC Article
  2. Bovine brain ribonuclease is the functional homolog of human ribonuclease 1. Eller CH, et al. J Biol Chem, 2014 Sep 19. PMID 25078100, Free PMC Article
  3. Primary structure of a ribonuclease from bovine brain. Watanabe H, et al. J Biochem, 1988 Dec. PMID 3243767
  4. Molecular cloning of the gene encoding the bovine brain ribonuclease and its expression in different regions of the brain. Sasso MP, et al. Nucleic Acids Res, 1991 Dec 11. PMID 1754384, Free PMC Article
  5. Correlation of folding kinetics with the number and isomerization states of prolines in three homologous proteins of the RNase family. Pradeep L, et al. FEBS Lett, 2006 Sep 18. PMID 16949585

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study concluded that brain ribonuclease (BRB) is a hormonally and developmentally regulated gene in bovine GCs and may regulate E2 production during follicular growth in cattle.
    Title: Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs.
  2. Brain ribonuclease, not RNase A, is the true bovine homolog of human RNase 1.
    Title: Bovine brain ribonuclease is the functional homolog of human ribonuclease 1.
  3. Data show that angiogenin isolated from cow milk induces the production of cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in human leukocytes.
    Title: Cow milk angiogenin induces cytokine production in human blood leukocytes.
  4. A direct correlation between the number of cis-prolyl bonds in a native protein and the complexity with which it folds is shown in the folding of three structurally homologous proteins of the ribonuclease family, namely RNase A, onconase and angiogenin.
    Title: Correlation of folding kinetics with the number and isomerization states of prolines in three homologous proteins of the RNase family.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC140149

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
brain ribonuclease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173891.2 → NP_776316.1  brain ribonuclease precursor

    See identical proteins and their annotated locations for NP_776316.1

    Status: PROVISIONAL

    Source sequence(s)
    BC114791
    UniProtKB/Swiss-Prot
    P39873, Q1RMP6
    Conserved Domains (1) summary
    smart00092
    Location:27 → 150
    RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26256262..26257893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997226.2 → XP_024852994.1  brain ribonuclease isoform X1

    UniProtKB/Swiss-Prot
    P39873, Q1RMP6
    Related
    ENSBTAP00000006510.3, ENSBTAT00000006510.5
    Conserved Domains (1) summary
    smart00092
    Location:27 → 150
    RNAse_Pc; Pancreatic ribonuclease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39873.3 GenPept UniProtKB/Swiss-Prot:P39873

Gene LinkOut

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Molecular Biology Databases
Research Materials