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kars1 lysyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

Gene ID: 280647, updated on 9-Dec-2024

Summary

Official Symbol
kars1provided by ZNC
Official Full Name
lysyl-tRNA synthetase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-021115-8
See related
Ensembl:ENSDARG00000103799 AllianceGenome:ZFIN:ZDB-GENE-021115-8
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kars; cb530; zgc:92483; wu:fa16h02
Summary
Predicted to enable ATP:ADP adenylyltransferase activity; lysine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in several processes, including diadenosine tetraphosphate biosynthetic process; lysyl-tRNA aminoacylation; and positive regulation of macrophage activation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See kars1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (67429430..67448884)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (67206068..67225532)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease 1 like 2b Neighboring gene proteasome 26S subunit, non-ATPase 7 Neighboring gene nuclear factor of activated T cells 5b Neighboring gene small nucleolar RNA MBII-202 Neighboring gene glycine cleavage system protein H (aminomethyl carrier), b Neighboring gene ribosomal protein L13

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP:ADP adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in basophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diadenosine tetraphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lysyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lysyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage activation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
lysine--tRNA ligase
NP_001002386.1
NP_001315435.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002386.2NP_001002386.1  lysine--tRNA ligase isoform 1

    See identical proteins and their annotated locations for NP_001002386.1

    Status: VALIDATED

    Source sequence(s)
    BC076028, CABZ01060768, CU651676
    UniProtKB/TrEMBL
    A0A8M1N092, Q6DHE6
    Related
    ENSDARP00000136176.1, ENSDART00000162553.2
    Conserved Domains (3) summary
    PLN02502
    Location:34590
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:250588
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:139247
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
  2. NM_001328506.1NP_001315435.1  lysine--tRNA ligase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC076028, CABZ01060768, CU651676
    UniProtKB/TrEMBL
    A0A0R4IC11, A0A8M1P3X7
    Related
    ENSDARP00000144447.1, ENSDART00000178646.2
    Conserved Domains (3) summary
    PLN02502
    Location:9565
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:225563
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:114222
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    67429430..67448884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)