Selenoi selenoprotein I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Selenoiprovided by MGI
Official Full Name: selenoprotein Iprovided by MGI
Primary source: MGI:MGI:107898
See related: Ensembl:ENSMUSG00000075703 AllianceGenome:MGI:107898
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ept1; SELI; D5Wsu178e; mKIAA1724; 4933402G07Rik
Summary: The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Expression: Ubiquitous expression in CNS E18 (RPKM 9.7), large intestine adult (RPKM 8.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 16.22 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (30437579..30477428)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (30232581..30272430)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocyte-specific Selenoi deficiency predisposes mice to hepatic steatosis and obesity.
Title: Hepatocyte-specific Selenoi deficiency predisposes mice to hepatic steatosis and obesity.
Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination.
Title: Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination.
Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.
Title: Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.
Selenoprotein I (selenoi) as a critical enzyme in the central nervous system.
Title: Selenoprotein I (selenoi) as a critical enzyme in the central nervous system.
Selenoprotein I is essential for murine embryogenesis.
Title: Selenoprotein I is essential for murine embryogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124759 (e-PCR)
- UniSTS:161581

AI452230 (e-PCR)
- UniSTS:159354

AI448296 (e-PCR)
- UniSTS:159355

NoName (e-PCR)
- UniSTS:488576

NoName (e-PCR)
- UniSTS:235152

RH126690 (e-PCR)
- UniSTS:207766

Ept1 (e-PCR), detects polymorphism
- UniSTS:546761

RH125817 (e-PCR)
- UniSTS:142570

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ethanolaminephosphotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolaminephosphotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ethanolaminephosphotransferase activity	ISO Inferred from Sequence Orthology more info
enables ethanolaminephosphotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ether lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ethanolaminephosphotransferase 1

Names: ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

NP_081928.2

EC 2.7.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027652.3 → NP_081928.2 ethanolaminephosphotransferase 1

See identical proteins and their annotated locations for NP_081928.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the selenoprotein encoding transcript.

Source sequence(s)

AC241618, AK122544, AK133635, BC078438, BY136287

Consensus CDS

CCDS51451.1

UniProtKB/Swiss-Prot

Q3KQQ5, Q80TA1, Q8BG08

Related

ENSMUSP00000118368.3, ENSMUST00000145167.9

Conserved Domains (1) summary

cl00453
Location:6 → 312

CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RNA

NR_137634.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon and uses an alternate donor splice site at another internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC241618, AK014530, AK122544, AK133635, BC078438, BY136287