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AsnS Asparagine synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768965, updated on 4-Jan-2025

Summary

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Official Symbol
AsnSprovided by FlyBase
Official Full Name
Asparagine synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0270926
Locus tag
Dmel_CG33486
See related
AllianceGenome:FB:FBgn0270926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AS; asparagine-synthetase; CG33486; Dmel\CG33486
Summary
Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AsnS in Genome Data Viewer
Location:
78C1-78C2; 3-47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21173118..21174973)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21166218..21168073)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene uncharacterized protein Neighboring gene Adenylyl cyclase 78C Neighboring gene chromosome bows Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene parkin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster. Inoue YH, et al. J Cell Biol, 2000 Apr 3. PMID 10747094, Free PMC Article
  2. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378
  3. Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila. Boomgarden AC, et al. BMC Genomics, 2019 Jan 7. PMID 30616504, Free PMC Article
  4. Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase. Bu S, et al. Cell Rep, 2022 May 31. PMID 35649352
  5. Mating alters gene expression patterns in Drosophila melanogaster male heads. Ellis LL, et al. BMC Genomics, 2010 Oct 11. PMID 20937114, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables asparagine synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asparagine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparagine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
asparagine synthetase
Names
AsnS-PA
CG33486-PA
asparagine-synthetase
NP_996132.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21173118..21174973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206410.2 → NP_996132.1  asparagine synthetase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996132.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTW9
    Conserved Domains (3) summary
    PRK09431
    Location:1 → 554
    asnB; asparagine synthetase B; Provisional
    cd00712
    Location:2 → 182
    AsnB; Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a ...
    pfam00733
    Location:225 → 528
    Asn_synthase; Asparagine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTW9 Q7KTW9

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