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Pura Puratrophin-1-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768948, updated on 4-Jan-2025

Summary

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Official Symbol
Puraprovided by FlyBase
Official Full Name
Puratrophin-1-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0035802
Locus tag
Dmel_CG33275
See related
AllianceGenome:FB:FBgn0035802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33167; CG33275; CG7511; CG7513; CG7515; CG7520; Dmel\CG33275
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis; neuron projection morphogenesis; and regulation of locomotor rhythm. Is expressed in several structures, including adult heart; cuboidal/columnar epithelium; embryonic head epidermis; glial cell; and imaginal disc. Orthologous to several human genes including PLEKHG4B (pleckstrin homology and RhoGEF domain containing G4B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pura in Genome Data Viewer
Location:
66A6-66A8; 3-21 cM
Exon count:
20
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7593091..7639573)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7586191..7632673)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene missing minor mitochondria Neighboring gene testis-specific gamma-tubulin ring protein 84 Neighboring gene long non-coding RNA:CR45866 Neighboring gene ncRNA Neighboring gene Ubiquitin-related modifier 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II. Carnesecchi J, et al. Nucleic Acids Res, 2022 Jan 25. PMID 34931250, Free PMC Article
  2. A comparison of midline and tracheal gene regulation during Drosophila development. Long SK, et al. PLoS One, 2014. PMID 24465586, Free PMC Article
  3. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
  4. Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila. Hoedjes KM, et al. Evol Lett, 2019 Dec. PMID 31867121, Free PMC Article
  5. Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates. Watson JD, et al. Development, 2011 Apr. PMID 21350018, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of locomotor rhythm IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Puratrophin-1-like
Names
CG33275-PA
CG33275-PB
CG33275-PC
CG33275-PD
Pura-PA
Pura-PB
Pura-PC
Pura-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7593091..7639573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206294.3 → NP_996016.2  Puratrophin-1-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996016.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KU89
    Conserved Domains (4) summary
    cd13242
    Location:1524 → 1663
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00169
    Location:1562 → 1655
    PH; PH domain
    pfam00621
    Location:1353 → 1532
    RhoGEF; RhoGEF domain
    cl02563
    Location:15 → 52
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. NM_001274604.1 → NP_001261533.1  Puratrophin-1-like, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEF7
    Conserved Domains (3) summary
    cd13242
    Location:1518 → 1657
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00169
    Location:1556 → 1649
    PH; PH domain
    pfam00621
    Location:1347 → 1526
    RhoGEF; RhoGEF domain

  3. NM_206295.3 → NP_996017.2  Puratrophin-1-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996017.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R11, Q7KU88
    Conserved Domains (3) summary
    cd13242
    Location:1048 → 1187
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00169
    Location:1086 → 1179
    PH; PH domain
    pfam00621
    Location:877 → 1056
    RhoGEF; RhoGEF domain

  4. NM_206293.2 → NP_996015.1  Puratrophin-1-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996015.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KU87
    Conserved Domains (4) summary
    cd13242
    Location:492 → 631
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00169
    Location:530 → 623
    PH; PH domain
    pfam00621
    Location:321 → 500
    RhoGEF; RhoGEF domain
    cl03493
    Location:5 → 159
    Alpha_TIF; Alpha trans-inducing protein (Alpha-TIF)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEF7 M9PEF7
Q7KU87 Q7KU87
Q7KU88 Q7KU88
Q7KU89 Q7KU89
Q86NW6 Q86NW6
Q8MSF1 Q8MSF1

Gene LinkOut

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