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par-1 - par-1

Enables tau-protein kinase activity. Involved in several processes, including establishment of planar polarity; negative regulation of hippo signaling; and oogenesis. Located in several cellular components, including basolateral plasma membrane; fusome; and type I terminal bouton. Is expressed in several structures, including adult head; embryonic/larval anterior midgut; embryonic/larval fat body; fusome; and germline cell. Used to study neurodegenerative disease and visual impairment and progressive phthisis bulbi. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to several human genes including MARK1 (microtubule affinity regulating kinase 1) and MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa