Fancd2 Fancd2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fancd2provided by FlyBase
Official Full Name: Fancd2provided by FlyBase
Primary source: FLYBASE:FBgn0038827
Locus tag: Dmel_CG17269
See related: AllianceGenome:FB:FBgn0038827
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17269; CG31192; CG31194; Dmel\CG17269; dmFANCD2; FAD; FancD2; FANCD2
Summary: Predicted to enable DNA polymerase binding activity. Involved in interstrand cross-link repair and mitotic intra-S DNA damage checkpoint signaling. Predicted to be active in condensed chromosome and nucleus. Used to study Fanconi anemia and Fanconi anemia complementation group D2. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group D2; and breast cancer. Orthologous to human FANCD2 (FA complementation group D2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20810804..20816190, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16636526..16641912, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks.
Title: Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks.
FANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks.
Title: Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.
Fancd2 has a role in DNA repair.
Title: Drosophila homologs of FANCD2 and FANCL function in DNA repair.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA polymerase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair involved in meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous chromosome pairing at meiosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in interstrand cross-link repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

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