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HINT3 histidine triad nucleotide-binding 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 2746201, updated on 18-Sep-2024

Summary

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Official Symbol
HINT3
Official Full Name
histidine triad nucleotide-binding 3
Primary source
TAIR:AT5G48545
Locus tag
AT5G48545
See related
Araport:AT5G48545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
histidine triad nucleotide-binding 3
Summary
Encodes a protein that has adenylylsulfate sulfohydrolase activity (E.C. 3.6.2.1) in vitro.
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Genomic context

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See HINT3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (19675452..19678194)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene receptor-like protein kinase-related family protein Neighboring gene ncRNA Neighboring gene low-molecular-weight cysteine-rich 1 Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP). Guranowski A, et al. FEBS Lett, 2010 Jan 4. PMID 19896942
  2. In-depth proteome analysis of Arabidopsis leaf peroxisomes combined with in vivo subcellular targeting verification indicates novel metabolic and regulatory functions of peroxisomes. Reumann S, et al. Plant Physiol, 2009 May. PMID 19329564, Free PMC Article
  3. bHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis. Frerigmann H, et al. Plant Physiol, 2014 Sep. PMID 25049362, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_203178.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenylylsulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within purine ribonucleotide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histidine triad nucleotide-binding 3
NP_974907.1
  • histidine triad nucleotide-binding 3 (HINT3); CONTAINS InterPro DOMAIN/s: Histidine triad-like motif (InterPro:IPR011146), Histidine triad (HIT) protein (InterPro:IPR001310), Histidine triad, conserved site (InterPro:IPR019808), Histidine triad motif (InterPro:IPR011151); BEST Arabidopsis thaliana protein match is: HISTIDINE TRIAD NUCLEOTIDE-BINDING 2 (TAIR:AT1G31160.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19675452..19678194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344775.1 → NP_001330362.1  histidine triad nucleotide-binding 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BAL2, A0A7G2FGQ4

  2. NM_001344776.1 → NP_001330363.1  histidine triad nucleotide-binding 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BAL8

  3. NM_203178.3 → NP_974907.1  histidine triad nucleotide-binding 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4K1R2, Q8GWE2
    UniProtKB/TrEMBL
    A0A178UAY8, A0A178UD13, A0A5S9YC89
    Conserved Domains (1) summary
    cd01277
    Location:49 → 151
    HINT_subgroup; HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4K1R2.1

Gene LinkOut

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