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ATHAL3B Flavoprotein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 2745818, updated on 18-Sep-2024

Summary

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Official Symbol
ATHAL3B
Official Full Name
Flavoprotein
Primary source
TAIR:AT1G48605
Locus tag
AT1G48605
See related
Araport:AT1G48605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
HAL3; HAL3B; HALOTOLERANCE DETERMINANT 3; HALOTOLERANCE DETERMINANT 3B
Summary
Encodes a protein similar to yeast HAL3, which regulates the cell cycle and tolerance to salt stress through inhibition of the PPZ1 type-1 protein phosphatase. AtHAL3b mRNA levels are induced by salt stress. HAL3B presumably encodes for phosphopantothenoylcysteine decarboxylase being involved in Coenzyme A biosynthesis as indicated by functional complementation of a double mutant hal3 aaBb.
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Genomic context

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See ATHAL3B in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (17969395..17970551, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene AT hook motif-containing protein Neighboring gene high mobility group A5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. Rubio S, et al. Plant Physiol, 2006 Mar. PMID 16415216, Free PMC Article
  2. The X-ray structure of the FMN-binding protein AtHal3 provides the structural basis for the activity of a regulatory subunit involved in signal transduction. Albert A, et al. Structure, 2000 Sep 15. PMID 10986463
  3. Arabidopsis thaliana AtHAL3: a flavoprotein related to salt and osmotic tolerance and plant growth. Espinosa-Ruiz A, et al. Plant J, 1999 Dec. PMID 10652125
  4. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Santolaria C, et al. Sci Rep, 2018 Oct 2. PMID 30279472, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HAL3B is involved in coenzyme A biosynthesis and are therefore critical to early postgerminative growth.
    Title: An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_202265.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables FMN binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphopantothenoylcysteine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopantothenoylcysteine decarboxylase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within coenzyme A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic salinity response IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Flavoprotein
NP_973994.1
  • ATHAL3B; CONTAINS InterPro DOMAIN/s: Flavoprotein (InterPro:IPR003382); BEST Arabidopsis thaliana protein match is: HAL3-like protein A (TAIR:AT3G18030.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    17969395..17970551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202265.3 → NP_973994.1  Flavoprotein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P94063, Q9LP62
    UniProtKB/TrEMBL
    A0A178WCJ4, A0A5S9WPZ3, A0A654EGU9
    Conserved Domains (1) summary
    cl19190
    Location:1 → 201
    Flavoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P94063.2

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