U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF330 zinc finger protein 330 [ Homo sapiens (human) ]

Gene ID: 27309, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF330provided by HGNC
Official Full Name
zinc finger protein 330provided by HGNC
Primary source
HGNC:HGNC:15462
See related
Ensembl:ENSG00000109445 MIM:609550; AllianceGenome:HGNC:15462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOA36; HSA6591
Summary
Predicted to enable zinc ion binding activity. Located in chromosome, centromeric region; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart (RPKM 28.5), thyroid (RPKM 16.5) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF330 in Genome Data Viewer
Location:
4q31.21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (141220535..141234697)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (144540345..144554401)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (142142049..142155851)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 9 Neighboring gene uncharacterized LOC124900786 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:141677237-141677879 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:141677880-141678521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:141746857-141747378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:141747379-141747899 Neighboring gene Sharpr-MPRA regulatory region 7410 Neighboring gene ring finger protein 150 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:141972205-141972434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15715 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:142141834-142142340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:142142341-142142845 Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:142252666-142253865 Neighboring gene long intergenic non-protein coding RNA 2432

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genomic structure and chromosome location of the human gene encoding the zinc finger autoantigen ZNF330. Bolívar J, et al. Cytogenet Cell Genet, 2001. PMID 11528117
  2. NOA36 protein contains a highly conserved nucleolar localization signal capable of directing functional proteins to the nucleolus, in mammalian cells. de Melo IS, et al. PLoS One, 2013. PMID 23516598, Free PMC Article
  3. NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic activity in human cells. de Melo IS, et al. Biochim Biophys Acta, 2009 Dec. PMID 19895853
  4. ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells. Sanchez-Briñas A, et al. Biol Direct, 2023 May 30. PMID 37254218, Free PMC Article
  5. Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans. Bolívar J, et al. J Biol Chem, 1999 Dec 17. PMID 10593942

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells.
    Title: ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells.
  2. NOA36 protein contains a highly conserved nucleolar localization signal capable of directing functional proteins to the nucleolus, in mammalian cells.
    Title: NOA36 protein contains a highly conserved nucleolar localization signal capable of directing functional proteins to the nucleolus, in mammalian cells.
  3. NOA36/ZNF330 is translocated from the mitochondria to the cytoplasm when apoptosis is induced and that it contributes to cytochrome c release.
    Title: NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic activity in human cells.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of conduct disorder symptomatology.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 330
Names
nucleolar autoantigen 36
nucleolar cysteine-rich protein
zinc finger autoantigen 330

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292002.2 → NP_001278931.1  zinc finger protein 330 isoform 2

    See identical proteins and their annotated locations for NP_001278931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AJ006591, AK002106, AK223609, AK294089, BC004421, BU532661
    UniProtKB/TrEMBL
    B4DFG9
    Conserved Domains (1) summary
    pfam06524
    Location:11 → 208
    NOA36; NOA36 protein

  2. NM_014487.6 → NP_055302.1  zinc finger protein 330 isoform 1

    See identical proteins and their annotated locations for NP_055302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AJ006591, AK002106, AK223609, BC004421, BU532661
    Consensus CDS
    CCDS3754.1
    UniProtKB/Swiss-Prot
    B2RDA3, Q9Y3S2
    UniProtKB/TrEMBL
    Q53EN0
    Related
    ENSP00000262990.4, ENST00000262990.9
    Conserved Domains (1) summary
    pfam06524
    Location:1 → 268
    NOA36; NOA36 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    141220535..141234697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008033.2 → XP_016863522.1  zinc finger protein 330 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA3, Q9Y3S2
    UniProtKB/TrEMBL
    Q53EN0
    Conserved Domains (1) summary
    pfam06524
    Location:1 → 268
    NOA36; NOA36 protein

  2. XM_024453986.2 → XP_024309754.1  zinc finger protein 330 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA3, Q9Y3S2
    UniProtKB/TrEMBL
    Q53EN0
    Conserved Domains (1) summary
    pfam06524
    Location:1 → 268
    NOA36; NOA36 protein

  3. XM_047450073.1 → XP_047306029.1  zinc finger protein 330 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA3, Q9Y3S2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    144540345..144554401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349699.1 → XP_054205674.1  zinc finger protein 330 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA3, Q9Y3S2

  2. XM_054349697.1 → XP_054205672.1  zinc finger protein 330 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA3, Q9Y3S2

  3. XM_054349698.1 → XP_054205673.1  zinc finger protein 330 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA3, Q9Y3S2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y3S2.1 GenPept UniProtKB/Swiss-Prot:Q9Y3S2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools