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ADAMDEC1 ADAM like decysin 1 [ Homo sapiens (human) ]

Gene ID: 27299, updated on 27-Nov-2024

Summary

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Official Symbol
ADAMDEC1provided by HGNC
Official Full Name
ADAM like decysin 1provided by HGNC
Primary source
HGNC:HGNC:16299
See related
Ensembl:ENSG00000134028 MIM:606393; AllianceGenome:HGNC:16299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M12.219
Summary
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 233.3), colon (RPKM 104.6) and 4 other tissues See more
Orthologs
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Genomic context

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See ADAMDEC1 in Genome Data Viewer
Location:
8p21.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (24384285..24406013)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (24659416..24681139)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (24241798..24263526)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986931 Neighboring gene uncharacterized LOC105379328 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:23963874-23964511 Neighboring gene MPRA-validated peak6951 silencer Neighboring gene ADAM7, ADAMDEC1 and ADAM28 antisense RNA 1 Neighboring gene ADAM metallopeptidase domain 28 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:24244666-24245865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:24312019-24312518 Neighboring gene ADAM metallopeptidase domain 7 Neighboring gene ADAM7 antisense RNA 2 Neighboring gene uncharacterized LOC107986932

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity. Lund J, et al. J Biol Chem, 2013 Jul 19. PMID 23754285, Free PMC Article
  2. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. Mueller CG, et al. J Exp Med, 1997 Aug 29. PMID 9271581, Free PMC Article
  3. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. Fritsche J, et al. Immunology, 2003 Dec. PMID 14632642, Free PMC Article
  4. Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors. Lund J, et al. J Biol Chem, 2015 Mar 6. PMID 25564618, Free PMC Article
  5. ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells. Yako Y, et al. Sci Rep, 2018 Jun 25. PMID 29941981, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
    Title: Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
  2. ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/beta-catenin signaling via negative modulation of GSK-3beta.
    Title: ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.
  3. Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway.
    Title: Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway.
  4. Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro.
    Title: Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro.
  5. ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.
    Title: ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.
  6. The ADAMDEC1 plays a pro-inflammatory role in rosacea via modulating the M1 polarization of macrophages.
    Title: ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages.
  7. ADAMDEC1 is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells
    Title: ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells.
  8. Data show the critical pathways regulating the expression of ADAMDEC1 and the roles of enhancer RNAs and mechanistically links E1A binding protein p300 (p300) and enhancer RNAs, which is dependent on NF-kappa B (NFkappaB).
    Title: Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1.
  9. Data suggest that activated platelets release ADAMDEC1, which hydrolyzes pro-EGF (epidermal growth factor) to soluble, active HMW-EGF; proteolytic cleavage of pro-EGF first occurs at the C-terminal arginyl residue of the EGF domain; proteolysis is the regulated, rate-limiting step in generating soluble EGF from activated platelets.
    Title: The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.
  10. We hypothesize that these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metalloprotease inhibitors
    Title: Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Clone Names

  • FLJ79219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADAM DEC1
Names
ADAM-like protein decysin-1
a disintegrin and metalloproteinase domain-like protein decysin-1
decysin
disintegrin protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145271.2 → NP_001138743.1  ADAM DEC1 isoform 2

    See identical proteins and their annotated locations for NP_001138743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon compared to variant 1. Translation may initiate at an internal AUG site (compared to variant 1) due to leaky scanning as both AUG sites are associated with a weak Kozak signal. It is possible that this transcript is not protein-coding as initiation from the AUG site in exon 1 would render the transcript a candidate for nonsense-mediated decay. The same protein isoform is predicted for transcript variants 2 and 3.
    Source sequence(s)
    AK301007, AK316322
    Consensus CDS
    CCDS55212.1
    UniProtKB/TrEMBL
    B7Z6V5
    Conserved Domains (4) summary
    cd04269
    Location:139 → 330
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:139 → 333
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:3 → 93
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:350 → 382
    Disintegrin; Disintegrin

  2. NM_001145272.2 → NP_001138744.1  ADAM DEC1 isoform 2

    See identical proteins and their annotated locations for NP_001138744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) omits an alternate exon compared to variant 1. Translation may initiate at an internal AUG site (compared to variant 1) due to leaky scanning as both AUG sites are associated with a weak Kozak signal. It is possible that this transcript is not protein-coding as initiation from the AUG site in exon 1 would render the transcript a candidate for nonsense-mediated decay. The same protein isoform is predicted for transcript variants 2 and 3.
    Source sequence(s)
    AK301007, BC069582
    Consensus CDS
    CCDS55212.1
    UniProtKB/TrEMBL
    B7Z6V5
    Related
    ENSP00000428993.1, ENST00000522298.1
    Conserved Domains (4) summary
    cd04269
    Location:139 → 330
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:139 → 333
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:3 → 93
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:350 → 382
    Disintegrin; Disintegrin

  3. NM_014479.3 → NP_055294.1  ADAM DEC1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is predicted to encode the longer protein isoform (1) using a translation initiation site in the first exon.
    Source sequence(s)
    AK301007, BC069582, DC387711, Y13323
    Consensus CDS
    CCDS6044.1
    UniProtKB/Swiss-Prot
    B7ZAK5, O15204
    UniProtKB/TrEMBL
    B7Z6V5
    Related
    ENSP00000256412.4, ENST00000256412.8
    Conserved Domains (4) summary
    cd04269
    Location:218 → 409
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:218 → 412
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:54 → 172
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:429 → 461
    Disintegrin; Disintegrin

RNA

  1. NR_156422.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI801375, BX106677, BX481660, Y13323

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    24384285..24406013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    24659416..24681139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15204.2 GenPept UniProtKB/Swiss-Prot:O15204

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