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Kcnh3 potassium voltage-gated channel subfamily H member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 27150, updated on 27-Nov-2024

Summary

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Symbol
Kcnh3provided by RGD
Full Name
potassium voltage-gated channel subfamily H member 3provided by RGD
Primary source
RGD:71070
See related
EnsemblRapid:ENSRNOG00000057315 AllianceGenome:RGD:71070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bec1; Elk2
Summary
Enables inward rectifier potassium channel activity. Involved in potassium ion transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH3 (potassium voltage-gated channel subfamily H member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 91.1) See more
Orthologs
human mouse all
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Genomic context

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See Kcnh3 in Genome Data Viewer
Location:
7q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132244492..132262725)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130365593..130383859)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140788987..140910426)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA70 Neighboring gene microspherule protein 1 Neighboring gene pre-mRNA processing factor 40 homolog B Neighboring gene family with sequence similarity 186, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. Engeland B, et al. J Physiol, 1998 Dec 15. PMID 9824707, Free PMC Article
  2. Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia. Shi W, et al. J Physiol, 1998 Sep 15. PMID 9714851, Free PMC Article
  3. New ether-à-go-go K(+) channel family members localized in human telencephalon. Miyake A, et al. J Biol Chem, 1999 Aug 27. PMID 10455180
  4. Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. Wulfsen I, et al. J Neuroendocrinol, 2000 Mar. PMID 10718922
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-gated inwardly rectifying potassium channel KCNH3; potassium voltage-gated channel subfamily H member 3
Names
ELK channel 2
brain-specific eag-like channel 1
ether-a-go-go-like potassium channel 2
potassium channel, voltage gated eag related subfamily H, member 3
potassium voltage-gated channel, subfamily H (eag-related), member 3
rElk2
voltage-gated potassium channel subunit Kv12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017108.1 → NP_058804.1  voltage-gated inwardly rectifying potassium channel KCNH3

    See identical proteins and their annotated locations for NP_058804.1

    Status: PROVISIONAL

    Source sequence(s)
    AB022697
    UniProtKB/Swiss-Prot
    O89047
    Related
    ENSRNOP00000071001.1, ENSRNOT00000086611.3
    Conserved Domains (5) summary
    cd00038
    Location:585 → 695
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:42 → 133
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:246 → 514
    Ion_trans; Ion transport protein
    pfam07885
    Location:455 → 509
    Ion_trans_2; Ion channel
    pfam08447
    Location:42 → 123
    PAS_3; PAS fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    132244492..132262725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078511.2 → XP_038934439.1  potassium voltage-gated channel subfamily H member 3 isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:167 → 594
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:4 → 74
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:549 → 644
    cyc_nuc_ocin; bacteriocin-type transport-associated protein

  2. XM_017594683.3 → XP_017450172.1  potassium voltage-gated channel subfamily H member 3 isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:167 → 594
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:4 → 74
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:549 → 644
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89047.1 GenPept UniProtKB/Swiss-Prot:O89047

Gene LinkOut

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