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Zbtb11 zinc finger and BTB domain containing 11 [ Mus musculus (house mouse) ]

Gene ID: 271377, updated on 27-Nov-2024

Summary

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Official Symbol
Zbtb11provided by MGI
Official Full Name
zinc finger and BTB domain containing 11provided by MGI
Primary source
MGI:MGI:2443876
See related
Ensembl:ENSMUSG00000022601 AllianceGenome:MGI:2443876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZNF-U69274; 9230110G02Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in central nervous system; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 69. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 7.2), cerebellum adult (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb11 in Genome Data Viewer
Location:
16 C1.1; 16 33.74 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55791820..55829276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (55971437..56008913)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41050 Neighboring gene STARR-positive B cell enhancer ABC_E2466 Neighboring gene predicted gene 6958 Neighboring gene STARR-positive B cell enhancer ABC_E4180 Neighboring gene ribosomal protein L24 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_41052 Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene STARR-positive B cell enhancer ABC_E10912 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene predicted gene, 22422

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification. Cao H, et al. Blood Adv, 2023 Nov 14. PMID 37567157, Free PMC Article
  2. Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family. Balcarek JM, et al. Nucleic Acids Res, 1985 Aug 12. PMID 2994002, Free PMC Article
  3. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. Garipler G, et al. Cell Rep, 2022 Mar 15. PMID 35294876, Free PMC Article
  4. Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Ficker M, et al. Dev Biol, 2004 Apr 1. PMID 15031101
  5. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification.
    Title: Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification.
  2. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
    Title: The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173026.2 → NP_766614.2  zinc finger and BTB domain-containing protein 11

    See identical proteins and their annotated locations for NP_766614.2

    Status: VALIDATED

    Source sequence(s)
    AC171202
    Consensus CDS
    CCDS49874.1
    UniProtKB/Swiss-Prot
    G5E8B9, Q8BZQ5
    Related
    ENSMUSP00000056923.8, ENSMUST00000050248.9
    Conserved Domains (6) summary
    COG5048
    Location:664 → 837
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:678 → 698
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18202
    Location:195 → 312
    BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
    pfam13465
    Location:897 → 920
    zf-H2C2_2; Zinc-finger double domain
    pfam17921
    Location:68 → 120
    Integrase_H2C2; Integrase zinc binding domain
    cl29137
    Location:367 → 421
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    55791820..55829276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159968.1 → XP_036015861.1  zinc finger and BTB domain-containing protein 11 isoform X1

    Conserved Domains (6) summary
    PRK12387
    Location:554 → 621
    PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
    sd00017
    Location:848 → 868
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18202
    Location:195 → 312
    BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
    pfam13465
    Location:888 → 911
    zf-H2C2_2; Zinc-finger double domain
    pfam17921
    Location:68 → 120
    Integrase_H2C2; Integrase zinc binding domain
    NF033845
    Location:371 → 502
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  2. XM_030249142.2 → XP_030105002.1  zinc finger and BTB domain-containing protein 11 isoform X2

    Conserved Domains (7) summary
    PRK12387
    Location:554 → 621
    PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
    COG5189
    Location:667 → 752
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:678 → 698
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18202
    Location:195 → 312
    BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
    pfam13465
    Location:662 → 687
    zf-H2C2_2; Zinc-finger double domain
    pfam17921
    Location:68 → 120
    Integrase_H2C2; Integrase zinc binding domain
    cl29137
    Location:367 → 421
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)

  3. XM_036159969.1 → XP_036015862.1  zinc finger and BTB domain-containing protein 11 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:380 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:1 → 28
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam13465
    Location:613 → 636
    zf-H2C2_2; Zinc-finger double domain
    NF033845
    Location:87 → 218
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

RNA

  1. XR_001781828.3 RNA Sequence

  2. XR_004939192.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8B9.1 GenPept UniProtKB/Swiss-Prot:G5E8B9

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